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Review

Visfatin: A Possible Role in Cardiovasculo-Metabolic Disorders

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Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon
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Department of Pharmacology and Therapeutics, Beirut Arab University, Beirut P.O. Box 11-5020, Lebanon
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Department of Biology, College of Science, United Arab Emirates University, Al-Ain P.O. Box 15551, UAE
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Department of Medical Laboratory Sciences, University of Sharjah, Sharjah P.O. Box 27272, UAE
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Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43, 07100 Sassari, Italy
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Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon
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Department of Pharmacology and Toxicology, Alexandria University, Alexandria 21521, El-Mesallah, Egypt
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Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar
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Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha P.O. Box 2713, Qatar
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Author to whom correspondence should be addressed.
Cells 2020, 9(11), 2444; https://doi.org/10.3390/cells9112444
Received: 21 September 2020 / Revised: 27 October 2020 / Accepted: 2 November 2020 / Published: 9 November 2020
(This article belongs to the Special Issue Oxidative Stress, Nutrition and Cardiovascular Diseases)
Visfatin/NAMPT (nicotinamide phosphoribosyltransferase) is an adipocytokine with several intriguing properties. It was first identified as pre-B-cell colony-enhancing factor but turned out to possess enzymatic functions in nicotinamide adenine dinucleotide biosynthesis, with ubiquitous expression in skeletal muscles, liver, cardiomyocytes, and brain cells. Visfatin exists in an intracellular (iNAMPT) and extracellular (eNAMPT) form. Intracellularly, visfatin/iNAMPT plays a regulatory role in NAD+ biosynthesis and thereby affects many NAD-dependent proteins such as sirtuins, PARPs, MARTs and CD38/157. Extracellularly, visfatin is associated with many hormone-like signaling pathways and activates some intracellular signaling cascades. Importantly, eNAMPT has been associated with several metabolic disorders including obesity and type 1 and 2 diabetes. In this review, a brief overview about visfatin is presented with special emphasis on its relevance to metabolic diseases. Visfatin/NAMPT appears to be a unique molecule with clinical significance with a prospective promising diagnostic, prognostic, and therapeutic applications in many cardiovasculo-metabolic disorders. View Full-Text
Keywords: visfatin/NAMPT; metabolic disorders; NAD+; sirtuins; PARPs/MARTs visfatin/NAMPT; metabolic disorders; NAD+; sirtuins; PARPs/MARTs
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MDPI and ACS Style

Dakroub, A.; A. Nasser, S.; Younis, N.; Bhagani, H.; Al-Dhaheri, Y.; Pintus, G.; Eid, A.A.; El-Yazbi, A.F.; Eid, A.H. Visfatin: A Possible Role in Cardiovasculo-Metabolic Disorders. Cells 2020, 9, 2444. https://doi.org/10.3390/cells9112444

AMA Style

Dakroub A, A. Nasser S, Younis N, Bhagani H, Al-Dhaheri Y, Pintus G, Eid AA, El-Yazbi AF, Eid AH. Visfatin: A Possible Role in Cardiovasculo-Metabolic Disorders. Cells. 2020; 9(11):2444. https://doi.org/10.3390/cells9112444

Chicago/Turabian Style

Dakroub, Ali, Suzanne A. Nasser, Nour Younis, Humna Bhagani, Yusra Al-Dhaheri, Gianfranco Pintus, Assaad A. Eid, Ahmed F. El-Yazbi, and Ali H. Eid 2020. "Visfatin: A Possible Role in Cardiovasculo-Metabolic Disorders" Cells 9, no. 11: 2444. https://doi.org/10.3390/cells9112444

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