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Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis
Open AccessReview

Cellular Senescence in Renal and Urinary Tract Disorders

1
Institut des Maladies Métaboliques et Cardiovasculaires, Inserm, Université Paul Sabatier, UMR 1048—I2MC, 31432 Toulouse, France
2
Urosphere SAS, Rue des Satellites, 31400 Toulouse, France
3
Department of Urology, Kidney Transplantation and Andrology, Toulouse Rangueil University Hospital, 31432 Toulouse, France
*
Author to whom correspondence should be addressed.
Cells 2020, 9(11), 2420; https://doi.org/10.3390/cells9112420
Received: 12 October 2020 / Revised: 2 November 2020 / Accepted: 4 November 2020 / Published: 5 November 2020
Cellular senescence is a state of cell cycle arrest induced by repetitive cell mitoses or different stresses, which is implicated in various physiological or pathological processes. The beneficial or adverse effects of senescent cells depend on their transitory or persistent state. Transient senescence has major beneficial roles promoting successful post-injury repair and inhibiting malignant transformation. On the other hand, persistent accumulation of senescent cells has been associated with chronic diseases and age-related illnesses like renal/urinary tract disorders. The deleterious effects of persistent senescent cells have been related, in part, to their senescence-associated secretory phenotype (SASP) characterized by the release of a variety of factors responsible for chronic inflammation, extracellular matrix adverse remodeling, and fibrosis. Recently, an increase in senescent cell burden has been reported in renal, prostate, and bladder disorders. In this review, we will summarize the molecular mechanisms of senescence and their implication in renal and urinary tract diseases. We will also discuss the differential impacts of transient versus persistent status of cellular senescence, as well as the therapeutic potential of senescent cell targeting in these diseases. View Full-Text
Keywords: senescence; aging; SASP; chronic kidney disease; urogenital disorders senescence; aging; SASP; chronic kidney disease; urogenital disorders
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MDPI and ACS Style

Santin, Y.; Lluel, P.; Rischmann, P.; Gamé, X.; Mialet-Perez, J.; Parini, A. Cellular Senescence in Renal and Urinary Tract Disorders. Cells 2020, 9, 2420.

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