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The Regulatory Properties of the Ccr4–Not Complex

Institute for Cancer and Genomic Sciences, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
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Cells 2020, 9(11), 2379; https://doi.org/10.3390/cells9112379
Received: 25 August 2020 / Revised: 21 October 2020 / Accepted: 26 October 2020 / Published: 29 October 2020
The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression. In the nucleus, it is involved in the regulation of the cell cycle, chromatin modification, activation and inhibition of transcription initiation, control of transcription elongation, RNA export, nuclear RNA surveillance, and DNA damage repair. In the cytoplasm, the Ccr4–Not complex plays a central role in mRNA decay and affects protein quality control. Most of our original knowledge of the Ccr4–Not complex is derived, primarily, from studies in yeast. More recent studies have shown that the mammalian complex has a comparable structure and similar properties. In this review, we summarize the evidence for the multiple roles of both the yeast and mammalian Ccr4–Not complexes, highlighting their similarities. View Full-Text
Keywords: Ccr4–Not complex; mRNA decay; deadenylation; transcription; cell cycle; chromatin modification; RNA export; DNA damage repair Ccr4–Not complex; mRNA decay; deadenylation; transcription; cell cycle; chromatin modification; RNA export; DNA damage repair
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MDPI and ACS Style

Chalabi Hagkarim, N.; Grand, R.J. The Regulatory Properties of the Ccr4–Not Complex. Cells 2020, 9, 2379. https://doi.org/10.3390/cells9112379

AMA Style

Chalabi Hagkarim N, Grand RJ. The Regulatory Properties of the Ccr4–Not Complex. Cells. 2020; 9(11):2379. https://doi.org/10.3390/cells9112379

Chicago/Turabian Style

Chalabi Hagkarim, Nafiseh; Grand, Roger J. 2020. "The Regulatory Properties of the Ccr4–Not Complex" Cells 9, no. 11: 2379. https://doi.org/10.3390/cells9112379

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