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Open AccessArticle

Mutual Interaction of Clinical Factors and Specific microRNAs to Predict Mild Cognitive Impairment in Patients Receiving Hemodialysis

1
Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
2
Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
3
Department of Laboratory Medicine, Chang-Gung Memorial Hospital at Linkou Medical Center and Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan 33303, Taiwan
4
Clinical Genomics & Proteomics Core Lab, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
5
Center of Cancer Program Development, E-Da Cancer Hospital, I-Shou University, Kaohsiung 833, Taiwan
6
Department of Electronic Engineering, National Kaohsiung University of Science and Technology, Kaohsiung 833, Taiwan
*
Author to whom correspondence should be addressed.
Cells 2020, 9(10), 2303; https://doi.org/10.3390/cells9102303
Received: 29 September 2020 / Revised: 12 October 2020 / Accepted: 13 October 2020 / Published: 15 October 2020
(This article belongs to the Special Issue Circulating RNAs in Health and Disease)
Cognitive impairment (CI) is not uncommon in dialysis patients. Various factors have been implicated. This study aims to examine mutual interaction of various clinical factors for CI in patients receiving hemodialysis. A total of 48 hemodialysis patients in outpatient clinic were recruited from 2015 to 2017. Demographics, circulating uremic toxin concentrations, miRNA concentrations, and nerve injury protein concentrations were collected. Clinical dementia rating (CDR) scores were used to stratify the functional scores of the patients. Receiver operating characteristic (ROC) analysis was used to evaluate diagnostic test performance for predicting dichotomous results, and cumulative ROC analysis was used to examine the combined contribution of clinical factors. CDR scale 0 included 15 patients (mean age, 59.1 years); CDR > 0.5 included 33 patients (mean age, 64.0 years). On cumulative ROC analysis, the major predictors of mild CI were hemoglobin, age, sex, homocysteine, neuron-specific enolase (NSE), and miR-486. The cumulative area under the curve (AUC) on combining hemoglobin, age, and miR-486 was the highest (0.897, 95% confidence interval 0.806–0.988). Two dichotomized variables reached 81.82% sensitivity and 86.67% specificity, with the likelihood ratio for positive and negative results being 6.14 and 0.21, respectively. In conclusion, hemoglobin, age, and miR-486 display high-degree combined effects on mild CI in patients receiving hemodialysis. View Full-Text
Keywords: mild cognitive impairment; hemodialysis unit; microRNAs mild cognitive impairment; hemodialysis unit; microRNAs
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Chen, J.-B.; Chang, C.-C.; Li, L.-C.; Lee, W.-C.; Lin, C.-N.; Li, S.-C.; Moi, S.-H.; Yang, C.-H. Mutual Interaction of Clinical Factors and Specific microRNAs to Predict Mild Cognitive Impairment in Patients Receiving Hemodialysis. Cells 2020, 9, 2303.

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