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Volume 9
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10.3390/cells9010050
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Review

Atherosclerosis and the Capillary Network; Pathophysiology and Potential Therapeutic Strategies

by
Tilman Ziegler
1,2,
Farah Abdel Rahman
1,
Victoria Jurisch
1 and
Christian Kupatt
1,2,*
1
Klinik & Poliklinik für Innere Medizin I, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany
2
DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, 80802 Munich, Germany
*
Author to whom correspondence should be addressed.
Cells 2020, 9(1), 50; https://doi.org/10.3390/cells9010050
Submission received: 30 November 2019 / Revised: 20 December 2019 / Accepted: 21 December 2019 / Published: 24 December 2019
(This article belongs to the Special Issue Arteriogenesis and Therapeutic Neovascularization)
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Abstract

Atherosclerosis and associated ischemic organ dysfunction represent the number one cause of mortality worldwide. While the key drivers of atherosclerosis, arterial hypertension, hypercholesterolemia and diabetes mellitus, are well known disease entities and their contribution to the formation of atherosclerotic plaques are intensively studied and well understood, less effort is put on the effect of these disease states on microvascular structure an integrity. In this review we summarize the pathological changes occurring in the vascular system in response to prolonged exposure to these major risk factors, with a particular focus on the differences between these pathological alterations of the vessel wall in larger arteries as compared to the microcirculation. Furthermore, we intend to highlight potential therapeutic strategies to improve microvascular function during atherosclerotic vessel disease.
Keywords: atherosclerosis; pericyte; rAAV; capillary; endothelial cells atherosclerosis; pericyte; rAAV; capillary; endothelial cells

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MDPI and ACS Style

Ziegler, T.; Abdel Rahman, F.; Jurisch, V.; Kupatt, C. Atherosclerosis and the Capillary Network; Pathophysiology and Potential Therapeutic Strategies. Cells 2020, 9, 50. https://doi.org/10.3390/cells9010050

AMA Style

Ziegler T, Abdel Rahman F, Jurisch V, Kupatt C. Atherosclerosis and the Capillary Network; Pathophysiology and Potential Therapeutic Strategies. Cells. 2020; 9(1):50. https://doi.org/10.3390/cells9010050

Chicago/Turabian Style

Ziegler, Tilman, Farah Abdel Rahman, Victoria Jurisch, and Christian Kupatt. 2020. "Atherosclerosis and the Capillary Network; Pathophysiology and Potential Therapeutic Strategies" Cells 9, no. 1: 50. https://doi.org/10.3390/cells9010050

APA Style

Ziegler, T., Abdel Rahman, F., Jurisch, V., & Kupatt, C. (2020). Atherosclerosis and the Capillary Network; Pathophysiology and Potential Therapeutic Strategies. Cells, 9(1), 50. https://doi.org/10.3390/cells9010050

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