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Roles of CD38 in the Immune Response to Infection

Department of Cell Biology, Physiology and Immunology, School of Biology, University of Barcelona, and Institute of Biomedicine of the University of Barcelona (IBUB), 08028 Barcelona, Spain
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Cells 2020, 9(1), 228; https://doi.org/10.3390/cells9010228
Received: 26 November 2019 / Revised: 12 January 2020 / Accepted: 14 January 2020 / Published: 16 January 2020
CD38 is a multifunctional protein widely expressed in cells from the immune system and as a soluble form in biological fluids. CD38 expression is up-regulated by an array of inflammatory mediators, and it is frequently used as a cell activation marker. Studies in animal models indicate that CD38 functional expression confers protection against infection by several bacterial and parasitic pathogens. In addition, infectious complications are associated with anti-CD38 immunotherapy. Although CD38 displays receptor and enzymatic activities that contribute to the establishment of an effective immune response, recent work raises the possibility that CD38 might also enhance the immunosuppressive potential of regulatory leukocytes. This review integrates the current knowledge on the diversity of functions mediated by CD38 in the host defense to infection. View Full-Text
Keywords: CD38; CD157; immune response; infection CD38; CD157; immune response; infection
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Glaría, E.; Valledor, A.F. Roles of CD38 in the Immune Response to Infection. Cells 2020, 9, 228.

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