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Down-Regulation of Phosphoribosyl Pyrophosphate Synthetase 1 Inhibits Neuroblastoma Cell Proliferation

by Jifu Li 1,†, Junhong Ye 1,2,†, Shunqin Zhu 1,3,* and Hongjuan Cui 1,4,5,6,*
1
State Key Laboratory of Silkworm Genome Biology, College of Biotechnology, Southwest University, Chongqing 400715, China
2
Biological Science Research Center, Southwest University, Chongqing 400715, China
3
School of Life Sciences, Southwest University, Chongqing 400715, China
4
Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Chongqing 400715, China
5
Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Southwest University, Chongqing 400715, China
6
Cancer Center, Medical Research Institute, Southwest University, Chongqing 400715, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Cells 2019, 8(9), 955; https://doi.org/10.3390/cells8090955
Received: 13 July 2019 / Revised: 17 August 2019 / Accepted: 20 August 2019 / Published: 22 August 2019
Phosphoribosyl pyrophosphate synthetase 1 (PRPS1) is a key enzyme in de novo nucleotide synthesis and nucleotide salvage synthesis pathways that are critical for purine and pyrimidine biosynthesis. Abnormally high expression of PRPS1 can cause many diseases, including hearing loss, hypotonia, and ataxia, in addition to being associated with neuroblastoma. However, the role of PRPS1 in neuroblastoma is still unclear. In this study, we found that PRPS1 was commonly expressed in neuroblastoma cells and was closely related to poor prognosis for cancer. Furthermore, down-regulation of PRPS1 inhibited neuroblastoma cell proliferation and tumor growth in vitro and in vivo via disturbing DNA synthesis. This study provides new insights into the treatment of neuroblastoma patients and new targets for drug development. View Full-Text
Keywords: phosphoribosyl pyrophosphate synthetase 1 (PRPS1); neuroblastoma; cell proliferation phosphoribosyl pyrophosphate synthetase 1 (PRPS1); neuroblastoma; cell proliferation
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Li, J.; Ye, J.; Zhu, S.; Cui, H. Down-Regulation of Phosphoribosyl Pyrophosphate Synthetase 1 Inhibits Neuroblastoma Cell Proliferation. Cells 2019, 8, 955.

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