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Open AccessArticle

Protein S100-A7 Derived from Digested Dentin Is a Critical Molecule for Dentin Pulp Regeneration

1
Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita-shi, Osaka 565 0871, Japan
2
Osaka Research Institute of Industrial Science and Technology, 1-6-50 Morinomiya, Jyoutou-ku, Oosaka-shi, Osaka 536 8853, Japan
3
Oral Biology, School of Dentistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
*
Author to whom correspondence should be addressed.
Cells 2019, 8(9), 1002; https://doi.org/10.3390/cells8091002
Received: 3 August 2019 / Revised: 22 August 2019 / Accepted: 28 August 2019 / Published: 29 August 2019
Dentin consists of inorganic hard tissue and organic dentin matrix components (DMCs). Various kinds of bioactive molecules are included in DMCs and some of them can be released after digestion by endogenous matrix metalloproteinases (MMPs) in the caries region. Digested DMCs induced by MMP20 have been reported to promote pulpal wound healing processes, but the released critical molecules responsible for this phenomenon are unclear. Here, we identified protein S100-A7 as a critical molecule for pulpal healing in digested DMCs by comprehensive proteomic approaches and following pulp capping experiments in rat molars. In addition, immunohistochemical results indicated the specific distribution of S100-A7 and receptor for advanced glycation end-products (RAGE) as receptor for S100-A7 in the early stage of the pulpal healing process, and following accumulation of CD146-positive stem cells in wounded pulp. Our findings indicate that protein S100-A7 released from dentin by MMP20 might play a key role in dentin pulp regeneration. View Full-Text
Keywords: wound healing; pulp capping materials; dentinogenesis; proteomics wound healing; pulp capping materials; dentinogenesis; proteomics
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MDPI and ACS Style

Komichi, S.; Takahashi, Y.; Okamoto, M.; Ali, M.; Watanabe, M.; Huang, H.; Nakai, T.; Cooper, P.; Hayashi, M. Protein S100-A7 Derived from Digested Dentin Is a Critical Molecule for Dentin Pulp Regeneration. Cells 2019, 8, 1002.

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