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Open AccessFeature PaperReview

Protective to a T: The Role of T Cells during Zika Virus Infection

by Ryan D. Pardy 1,2 and Martin J. Richer 1,2,*
Department of Microbiology & Immunology, McGill University, Montreal, QC H3A 2B4, Canada
Rosalind & Morris Goodman Cancer Research Centre, McGill University, Montreal, QC H3G 1Y6, Canada
Author to whom correspondence should be addressed.
Cells 2019, 8(8), 820;
Received: 4 July 2019 / Revised: 31 July 2019 / Accepted: 2 August 2019 / Published: 3 August 2019
(This article belongs to the Special Issue Zika Virus and Host Interactions)
CD4 and CD8 T cells are an important part of the host’s capacity to defend itself against viral infections. During flavivirus infections, T cells have been implicated in both protective and pathogenic responses. Given the recent emergence of Zika virus (ZIKV) as a prominent global health threat, the question remains as to how T cells contribute to anti-ZIKV immunity. Furthermore, high homology between ZIKV and other, co-circulating flaviviruses opens the possibility of positive or negative effects of cross-reactivity due to pre-existing immunity. In this review, we will discuss the CD4 and CD8 T cell responses to ZIKV, and the lessons we have learned from both mouse and human infections. In addition, we will consider the possibility of whether T cells, in the context of flavivirus-naïve and flavivirus-immune subjects, play a role in promoting ZIKV pathogenesis during infection. View Full-Text
Keywords: zika virus; flaviviruses; T cells; host-pathogen interactions zika virus; flaviviruses; T cells; host-pathogen interactions
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Pardy, R.D.; Richer, M.J. Protective to a T: The Role of T Cells during Zika Virus Infection. Cells 2019, 8, 820.

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