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Interplay between Zika Virus and Peroxisomes during Infection
Open AccessFeature PaperReview

Protective to a T: The Role of T Cells during Zika Virus Infection

Department of Microbiology & Immunology, McGill University, Montreal, QC H3A 2B4, Canada
Rosalind & Morris Goodman Cancer Research Centre, McGill University, Montreal, QC H3G 1Y6, Canada
Author to whom correspondence should be addressed.
Cells 2019, 8(8), 820;
Received: 4 July 2019 / Revised: 31 July 2019 / Accepted: 2 August 2019 / Published: 3 August 2019
(This article belongs to the Special Issue Zika Virus and Host Interactions)
PDF [431 KB, uploaded 3 August 2019]


CD4 and CD8 T cells are an important part of the host’s capacity to defend itself against viral infections. During flavivirus infections, T cells have been implicated in both protective and pathogenic responses. Given the recent emergence of Zika virus (ZIKV) as a prominent global health threat, the question remains as to how T cells contribute to anti-ZIKV immunity. Furthermore, high homology between ZIKV and other, co-circulating flaviviruses opens the possibility of positive or negative effects of cross-reactivity due to pre-existing immunity. In this review, we will discuss the CD4 and CD8 T cell responses to ZIKV, and the lessons we have learned from both mouse and human infections. In addition, we will consider the possibility of whether T cells, in the context of flavivirus-naïve and flavivirus-immune subjects, play a role in promoting ZIKV pathogenesis during infection. View Full-Text
Keywords: zika virus; flaviviruses; T cells; host-pathogen interactions zika virus; flaviviruses; T cells; host-pathogen interactions

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Pardy, R.D.; Richer, M.J. Protective to a T: The Role of T Cells during Zika Virus Infection. Cells 2019, 8, 820.

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