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Insights on CTC Biology and Clinical Impact Emerging from Advances in Capture Technology

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Marlene and Stewart Greenebaum Comprehensive Cancer Center, School of Medicine (UMGCCC), University of Maryland, Baltimore, MD 21201, USA
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Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
*
Author to whom correspondence should be addressed.
Cells 2019, 8(6), 553; https://doi.org/10.3390/cells8060553
Received: 16 May 2019 / Revised: 31 May 2019 / Accepted: 3 June 2019 / Published: 6 June 2019
Circulating tumor cells (CTCs) and circulating tumor microemboli (CTM) have been shown to correlate negatively with patient survival. Actual CTC counts before and after treatment can be used to aid in the prognosis of patient outcomes. The presence of circulating tumor materials (CTMat) can advertise the presence of metastasis before clinical presentation, enabling the early detection of relapse. Importantly, emerging evidence is indicating that cancer treatments can actually increase the incidence of CTCs and metastasis in pre-clinical models. Subsequently, the study of CTCs, their biology and function are of vital importance. Emerging technologies for the capture of CTC/CTMs and CTMat are elucidating vitally important biological and functional information that can lead to important alterations in how therapies are administered. This paves the way for the development of a “liquid biopsy” where treatment decisions can be informed by information gleaned from tumor cells and tumor cell debris in the blood. View Full-Text
Keywords: circulating tumor cells; CTC; liquid biopsy; CTM; CTMat; CTC biology; CTC capture technology circulating tumor cells; CTC; liquid biopsy; CTM; CTMat; CTC biology; CTC capture technology
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Bailey, P.C.; Martin, S.S. Insights on CTC Biology and Clinical Impact Emerging from Advances in Capture Technology. Cells 2019, 8, 553.

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