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Open AccessArticle

Distinct Expression of Inflammatory Features in T Helper 17 Cells from Multiple Sclerosis Patients

1
Neuroimmunology Unit, IRCSS Fondazione Santa Lucia, 00143 Rome, Italy
2
Department of Biology and Biotechnology Charles Darwin, Sapienza University, 00185 Rome, Italy
3
Department of Neuroscience “Lancisi”, San Camillo Hospital, 00152 Rome, Italy
4
Unit of Neurology, IRCCS Neuromed, 86077 Pozzilli (IS), Italy
5
Institute of Human Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
These authors contributed equally to this work.
Cells 2019, 8(6), 533; https://doi.org/10.3390/cells8060533
Received: 14 May 2019 / Revised: 28 May 2019 / Accepted: 1 June 2019 / Published: 4 June 2019
(This article belongs to the Special Issue The Molecular and Cellular Basis for Multiple Sclerosis)
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). T helper (Th) 17 lymphocytes play a role in the pathogenesis of MS. Indeed, Th17 cells are abundant in the cerebrospinal fluid and peripheral blood of MS patients and promote pathogenesis in the mouse model of MS. To gain insight into the function of Th17 cells in MS, we tested whether Th17 cells polarized from naïve CD4 T cells of healthy donors and MS patients display different features. To this end, we analysed several parameters that typify the Th17 profile during the differentiation process of naïve CD4 T cells obtained from relapsing-remitting (RR)-MS patients (n = 31) and healthy donors (HD) (n = 28). Analysis of an array of cytokines produced by Th17 cells revealed that expression of interleukin (IL)-21, tumour necrosis factor (TNF)-β, IL-2 and IL-1R1 is significantly increased in Th17 cells derived from MS patients compared to healthy donor-derived cells. Interestingly, IL-1R1 expression is also increased in Th17 cells circulating in the blood of MS patients compared to healthy donors. Since IL-2, IL-21, TNF-β, and IL-1R1 play a crucial role in the activation of immune cells, our data indicate that high expression of these molecules in Th17 cells from MS patients could be related to their high inflammatory status. View Full-Text
Keywords: multiple sclerosis; T helper -17 cells; interleukin-1 receptor; interleukin-2; interleukin-21; tumour necrosis factor-beta multiple sclerosis; T helper -17 cells; interleukin-1 receptor; interleukin-2; interleukin-21; tumour necrosis factor-beta
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Capone, A.; Bianco, M.; Ruocco, G.; De Bardi, M.; Battistini, L.; Ruggieri, S.; Gasperini, C.; Centonze, D.; Sette, C.; Volpe, E. Distinct Expression of Inflammatory Features in T Helper 17 Cells from Multiple Sclerosis Patients. Cells 2019, 8, 533.

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