Next Article in Journal
A Phase 2a, Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Trial of IBD98-M Delayed-Release Capsules to Induce Remission in Patients with Active and Mild to Moderate Ulcerative Colitis
Next Article in Special Issue
Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis
Previous Article in Journal
A Hybrid Prediction Method for Plant lncRNA-Protein Interaction
Previous Article in Special Issue
c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis
Open AccessReview

Pharmacogenetic-Based Interactions between Nutraceuticals and Angiogenesis Inhibitors

1
Gruppo Oncologico Ricercatori Italiani GORI, 33100 Pordenone, Italy
2
Department of Medical Oncology, National Cancer Institute, CRO 33018 Aviano, Italy
3
Pineta Grande Hospital, 81030 Castel Volturno, Caserta, Italy
4
Department of Urology, University Federico II of Napoli, 80126 Naples, Italy
5
Department of Biology and Biotechnology “L. Spallanzani”, University of Pavia, 27100 Pavia, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Nader Rahimi
Cells 2019, 8(6), 522; https://doi.org/10.3390/cells8060522
Received: 16 April 2019 / Revised: 20 May 2019 / Accepted: 24 May 2019 / Published: 30 May 2019
(This article belongs to the Special Issue Angiogenesis in Cancer)
Background: Angiogenesis inhibitors (AIs) have become established as an effective cancer treatment. Whereas their interactions with antineoplastic drugs have extensively been investigated, little is known of the effect of their co-administration with nutraceuticals/dietary supplements (N/DSs), which are often self-prescribed. N/DSs comprise a wide range of products such as herbs, nutrients, vitamins, minerals, and probiotics. Assessment of their interactions with cancer drugs, particularly AIs, is hampered by the difficulty of gauging the amount of active substances patients actually take. Moreover, there is no agreement on which approach should be used to determine which N/DSs are most likely to influence AI treatment efficacy. We present a comprehensive review of the metabolic routes of the major AIs and their possible interactions with N/DSs. Methods: The PubMed and Cochrane databases were searched for papers describing the metabolic routes of the main AIs and N/DSs. Results: Data from the 133 studies thus identified were used to compile a diagnostic table reporting known and expected AI-N/DS interactions based on their metabolization pathways. AIs and N/DSs sharing the cytochrome P450 pathway are at risk of negative interactions. Conclusions: Recent advances in pharmacogenetics offer exceptional opportunities to identify prognostic and predictive markers to enhance the efficacy of individualized AI treatments. The table provides a guide to genotyping patients who are due to receive AIs and is a promising tool to prevent occult AI-N/DS interactions in poor metabolizers. N/DS use by cancer patients receiving AIs is a topical problem requiring urgent attention from the scientific community. View Full-Text
Keywords: neoangiogenesis; complementary and alternative medicines (CAMs); targeted treatment; pharmacogenomics; cytochrome P450 polymorphisms; nutraceuticals; dietary supplements neoangiogenesis; complementary and alternative medicines (CAMs); targeted treatment; pharmacogenomics; cytochrome P450 polymorphisms; nutraceuticals; dietary supplements
Show Figures

Figure 1

MDPI and ACS Style

Di Francia, R.; Berretta, M.; Benincasa, G.; D’Avino, A.; Facchini, S.; Costagliola, D.; Rossi, P. Pharmacogenetic-Based Interactions between Nutraceuticals and Angiogenesis Inhibitors. Cells 2019, 8, 522.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop