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Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues

1
Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto 606-8501, Japan
2
Department of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan
3
Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90032, USA
*
Author to whom correspondence should be addressed.
Cells 2019, 8(5), 440; https://doi.org/10.3390/cells8050440
Received: 22 April 2019 / Revised: 7 May 2019 / Accepted: 7 May 2019 / Published: 10 May 2019
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Abstract

Chorioallantoic membrane assay (CAM assay) using fertilized chicken eggs has been used for the study of tumor formation, angiogenesis and metastasis. Recently, there is growing realization that this system provides a valuable assay for a patient-derived tumor model. Several reports establish that tumor samples from cancer patients can be used to reproduce tumor in the chicken egg. High transplantation efficiency has been achieved. In this review, we discuss examples of transplanting patient tumors. We then discuss critical issues that need to be addressed to pursue this line of experiments. The patient-derived chicken egg model (PDcE model) has an advantage over other models in its rapid tumor formation. This raises the possibility that the PDcE model is valuable for identifying optimum drug for each individual patient. View Full-Text
Keywords: CAM assay; tumor tissue; immunohistochemistry; patient tumor; H&E staining; angiogenesis; precision medicine; tailor-made drug CAM assay; tumor tissue; immunohistochemistry; patient tumor; H&E staining; angiogenesis; precision medicine; tailor-made drug
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Komatsu, A.; Matsumoto, K.; Saito, T.; Muto, M.; Tamanoi, F. Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues. Cells 2019, 8, 440.

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