Next Article in Journal
MAGI1 Mediates eNOS Activation and NO Production in Endothelial Cells in Response to Fluid Shear Stress
Previous Article in Journal
Rainbow Trout Red Blood Cells Exposed to Viral Hemorrhagic Septicemia Virus Up-Regulate Antigen-Processing Mechanisms and MHC I&II, CD86, and CD83 Antigen-presenting Cell Markers
Article Menu

Export Article

Open AccessFeature PaperReview

Motor Endplate—Anatomical, Functional, and Molecular Concepts in the Historical Perspective

1
Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, 68163 Mannheim, Germany
2
Interdisciplinary Center for Neuroscience, Heidelberg University, 69120 Heidelberg, Germany
3
Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, 76344 Eggenstein-Leopoldshafen, Germany
4
Cell Biology and Biophysics, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
5
Max Planck Institute for Medical Research, 69120 Heidelberg, Germany
*
Author to whom correspondence should be addressed.
Cells 2019, 8(5), 387; https://doi.org/10.3390/cells8050387
Received: 10 April 2019 / Revised: 20 April 2019 / Accepted: 25 April 2019 / Published: 27 April 2019
  |  
PDF [1301 KB, uploaded 27 April 2019]
  |     |  

Abstract

By mediating voluntary muscle movement, vertebrate neuromuscular junctions (NMJ) play an extraordinarily important role in physiology. While the significance of the nerve-muscle connectivity was already conceived almost 2000 years back, the precise cell and molecular biology of the NMJ have been revealed in a series of fascinating research activities that started around 180 years ago and that continues. In all this time, NMJ research has led to fundamentally new concepts of cell biology, and has triggered groundbreaking advancements in technologies. This review tries to sketch major lines of thought and concepts on NMJ in their historical perspective, in particular with respect to anatomy, function, and molecular components. Furthermore, along these lines, it emphasizes the mutual benefit between science and technology, where one drives the other. Finally, we speculate on potential major future directions for studies on NMJ in these fields. View Full-Text
Keywords: history; motor endplate; neuromuscular junction; skeletal muscle; sympathetic innervation; synapse history; motor endplate; neuromuscular junction; skeletal muscle; sympathetic innervation; synapse
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Rudolf, R.; Khan, M.M.; Witzemann, V. Motor Endplate—Anatomical, Functional, and Molecular Concepts in the Historical Perspective. Cells 2019, 8, 387.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top