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Cells 2019, 8(2), 157; https://doi.org/10.3390/cells8020157

Systematic Review of the Current Status of Human Sarcoma Cell Lines

1
Division of Rare Cancer Research, National Cancer Center Research Institute, Tokyo 1040045, Japan
2
Department of Innovative Seeds Evaluation, National Cancer Center Research Institute, Tokyo 1040045, Japan
*
Author to whom correspondence should be addressed.
Received: 29 December 2018 / Revised: 9 February 2019 / Accepted: 13 February 2019 / Published: 13 February 2019
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Abstract

Sarcomas are rare mesenchymal malignant tumors with unique biological and clinical features. Given their diversity, heterogeneity, complexity, and rarity, the clinical management of sarcomas is quite challenging. Cell lines have been used as indispensable tools for both basic research and pre-clinical studies. However, empirically, sarcoma cell lines are not readily available. To understand the present status of sarcoma cell lines and identify their current challenges, we systematically reviewed reports on sarcoma cell lines. We searched the cell line database, Cellosaurus, and categorized the sarcoma cell lines according to the WHO classification. We identified the number and availability of sarcoma cell lines with a specific histology. We found 844 sarcoma cell lines in the Cellosaurus database, and 819 of them were named according to the WHO classification. Among the 819 cell lines, 36 multiple and nine single cell lines are available for histology. No cell lines were reported for 133 of the histological subtypes. Among the 844 cell lines, 148 are currently available in public cell banks, with 692 already published. We conclude that there needs to be a larger number of cell lines, with various histological subtypes, to better benefit sarcoma research. View Full-Text
Keywords: sarcoma; patient-derived cancer model; cell line; cell bank; histological subtypes sarcoma; patient-derived cancer model; cell line; cell bank; histological subtypes
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Hattori, E.; Oyama, R.; Kondo, T. Systematic Review of the Current Status of Human Sarcoma Cell Lines. Cells 2019, 8, 157.

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