Polyamine Metabolism as a Therapeutic Target in Hedgehog-Driven Basal Cell Carcinoma and Medulloblastoma

Coni, Sonia; Di Magno, Laura; Serrao, Silvia Maria; Kanamori, Yuta; Agostinelli, Enzo; Canettieri, Gianluca

doi:10.3390/cells8020150

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Polyamine Metabolism as a Therapeutic Target in Hedgehog-Driven Basal Cell Carcinoma and Medulloblastoma

^1,†,

^2,†,

¹,

³,

^3,4,*

and

Gianluca Canettieri

^1,4,5,*

Department of Molecular Medicine, Sapienza University, 00161 Rome, Italy

Center for Life Nano [email protected], Istituto Italiano di Tecnologia, 00161 Rome, Italy

Department of Biochemical Sciences ‘A. Rossi Fanelli’, Sapienza University, 00185 Rome, Italy

⁴

International Polyamines Foundation—ONLUS—Via del Forte Tiburtino, 98, 00159 Rome, Italy

⁵

Pasteur Laboratory, Department of Molecular Medicine, Sapienza University, 00161 Rome, Italy

Authors to whom correspondence should be addressed.

^†

These Authors contributed equally to this work.

Cells 2019, 8(2), 150; https://doi.org/10.3390/cells8020150

Received: 11 January 2019 / Revised: 6 February 2019 / Accepted: 8 February 2019 / Published: 11 February 2019

(This article belongs to the Collection Hedgehog Signal Transduction in Physiology and Disease)

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Abstract

Hedgehog (Hh) signaling is a critical developmental regulator and its aberrant activation, due to somatic or germline mutations of genes encoding pathway components, causes Basal Cell Carcinoma (BCC) and medulloblastoma (MB). A growing effort has been devoted at the identification of druggable vulnerabilities of the Hedgehog signaling, leading to the identification of various compounds with variable efficacy and/or safety. Emerging evidence shows that an aberrant polyamine metabolism is a hallmark of Hh-dependent tumors and that its pharmacological inhibition elicits relevant therapeutic effects in clinical or preclinical models of BCC and MB. We discuss here the current knowledge of polyamine metabolism, its role in cancer and the available targeting strategies. We review the literature about the connection between polyamines and the Hedgehog signaling, and the potential therapeutic benefit of targeting polyamine metabolism in two malignancies where Hh pathways play a well-established role: BCC and MB. View Full-Text

Keywords: Hedgehog; polyamines; medulloblastoma; basal cell carcinoma; d,l-alpha-difluoromethylornithine

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MDPI and ACS Style

Coni, S.; Di Magno, L.; Serrao, S.M.; Kanamori, Y.; Agostinelli, E.; Canettieri, G. Polyamine Metabolism as a Therapeutic Target in Hedgehog-Driven Basal Cell Carcinoma and Medulloblastoma. Cells 2019, 8, 150. https://doi.org/10.3390/cells8020150

AMA Style

Coni S, Di Magno L, Serrao SM, Kanamori Y, Agostinelli E, Canettieri G. Polyamine Metabolism as a Therapeutic Target in Hedgehog-Driven Basal Cell Carcinoma and Medulloblastoma. Cells. 2019; 8(2):150. https://doi.org/10.3390/cells8020150

Chicago/Turabian Style

Coni, Sonia, Laura Di Magno, Silvia M. Serrao, Yuta Kanamori, Enzo Agostinelli, and Gianluca Canettieri. 2019. "Polyamine Metabolism as a Therapeutic Target in Hedgehog-Driven Basal Cell Carcinoma and Medulloblastoma" Cells 8, no. 2: 150. https://doi.org/10.3390/cells8020150

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Polyamine Metabolism as a Therapeutic Target in Hedgehog-Driven Basal Cell Carcinoma and Medulloblastoma

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