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Review

Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials

1
Guy Hilton Research Centre, School of Pharmacy & Bioengineering, Keele University, Staffordshire ST4 7QB, UK
2
RCSI Bahrain, P.O. Box 15503, Adliya, Bahrain
*
Author to whom correspondence should be addressed.
Cells 2019, 8(12), 1536; https://doi.org/10.3390/cells8121536
Received: 18 October 2019 / Revised: 20 November 2019 / Accepted: 21 November 2019 / Published: 28 November 2019
(This article belongs to the Special Issue Stem Cell Research on Cardiology)
Cardiac Progenitor Cells (CPCs) show great potential as a cell resource for restoring cardiac function in patients affected by heart disease or heart failure. CPCs are proliferative and committed to cardiac fate, capable of generating cells of all the cardiac lineages. These cells offer a significant shift in paradigm over the use of human induced pluripotent stem cell (iPSC)-derived cardiomyocytes owing to the latter’s inability to recapitulate mature features of a native myocardium, limiting their translational applications. The iPSCs and direct reprogramming of somatic cells have been attempted to produce CPCs and, in this process, a variety of chemical and/or genetic factors have been evaluated for their ability to generate, expand, and maintain CPCs in vitro. However, the precise stoichiometry and spatiotemporal activity of these factors and the genetic interplay during embryonic CPC development remain challenging to reproduce in culture, in terms of efficiency, numbers, and translational potential. Recent advances in biomaterials to mimic the native cardiac microenvironment have shown promise to influence CPC regenerative functions, while being capable of integrating with host tissue. This review highlights recent developments and limitations in the generation and use of CPCs from stem cells, and the trends that influence the direction of research to promote better application of CPCs. View Full-Text
Keywords: cardiac progenitor cells; induced pluripotent stem cells; transdifferentiation; direct reprogramming; genetic engineering; cardiac tissue engineering; biomaterials cardiac progenitor cells; induced pluripotent stem cells; transdifferentiation; direct reprogramming; genetic engineering; cardiac tissue engineering; biomaterials
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MDPI and ACS Style

Barreto, S.; Hamel, L.; Schiatti, T.; Yang, Y.; George, V. Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials. Cells 2019, 8, 1536. https://doi.org/10.3390/cells8121536

AMA Style

Barreto S, Hamel L, Schiatti T, Yang Y, George V. Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials. Cells. 2019; 8(12):1536. https://doi.org/10.3390/cells8121536

Chicago/Turabian Style

Barreto, Sara, Leonie Hamel, Teresa Schiatti, Ying Yang, and Vinoj George. 2019. "Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials" Cells 8, no. 12: 1536. https://doi.org/10.3390/cells8121536

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