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Open AccessArticle

Mathematical Model Explaining the Role of CDC6 in the Diauxic Growth of CDK1 Activity during the M-Phase of the Cell Cycle

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Faculty of Mathematics, Informatics and Mechanics, Institute of Applied Mathematics and Mechanics, University of Warsaw, ul. Banacha 2, 02-097 Warsaw, Poland
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Institute of Mathematics, Polish Academy of Sciences, ul. Śniadeckich 8, 00-656 Warsaw, Poland
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ICM, University of Warsaw, ul. Tyniecka 15/17, 02-630 Warsaw, Poland
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CNRS, Institute of Genetics and Development of Rennes, Univ Rennes, UMR 6290, Cell Cycle Group, Faculty of Medicine, F-35000 Rennes, France
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Laboratory of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology (WIHE), ul. Kozielska 4, 01-163 Warsaw, Poland
*
Authors to whom correspondence should be addressed.
Cells 2019, 8(12), 1537; https://doi.org/10.3390/cells8121537
Received: 6 November 2019 / Revised: 22 November 2019 / Accepted: 25 November 2019 / Published: 28 November 2019
(This article belongs to the Special Issue Manufacturing a Female Gamete: An Oocyte Story)
In this paper we propose a role for the CDC 6 protein in the entry of cells into mitosis. This has not been considered in the literature so far. Recent experiments suggest that CDC 6 , upon entry into mitosis, inhibits the appearance of active CDK 1 and cyclin B complexes. This paper proposes a mathematical model which incorporates the dynamics of kinase CDK 1 , its regulatory protein cyclin B, the regulatory phosphatase CDC 25 and the inhibitor CDC 6 known to be involved in the regulation of active CDK 1 and cyclin B complexes. The experimental data lead us to formulate a new hypothesis that CDC 6 slows down the activation of inactive complexes of CDK 1 and cyclin B upon mitotic entry. Our mathematical model, based on mass action kinetics, provides a possible explanation for the experimental data. We claim that the dynamics of active complexes CDK 1 and cyclin B have a similar nature to diauxic dynamics introduced by Monod in 1949. In mathematical terms we state it as the existence of more than one inflection point of the curve defining the dynamics of the complexes. View Full-Text
Keywords: cell cycle; M-phase entry; mathematical model; dynamical system; diauxic dynamics; CDC 6; CDK 1; Xenopus laevis embryo cell cycle; M-phase entry; mathematical model; dynamical system; diauxic dynamics; CDC 6; CDK 1; Xenopus laevis embryo
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Dębowski, M.; Szymańska, Z.; Kubiak, J.Z.; Lachowicz, M. Mathematical Model Explaining the Role of CDC6 in the Diauxic Growth of CDK1 Activity during the M-Phase of the Cell Cycle. Cells 2019, 8, 1537.

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