Next Article in Journal
An Autophagy Modifier Screen Identifies Small Molecules Capable of Reducing Autophagosome Accumulation in a Model of CLN3-Mediated Neurodegeneration
Next Article in Special Issue
Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials
Previous Article in Journal
Sex Differences in Liver, Adipose Tissue, and Muscle Transcriptional Response to Fasting and Refeeding in Mice
Previous Article in Special Issue
CD271+ Human Mesenchymal Stem Cells Show Antiarrhythmic Effects in a Novel Murine Infarction Model
Open AccessFeature PaperReview

Stem Cells in Cardiovascular Medicine: Historical Overview and Future Prospects

by 1,2 and 1,2,*
Department of Laboratory Animal Science, Leibnitz-Institut für Primatenforschung, Deutsches Primatenzentrum GmbH, Kellnerweg 4, 37077 Göttingen, Germany
DZHK (German Centre for Cardiovascular Research), Partner Site Göttingen, 37075 Göttingen, Germany
Author to whom correspondence should be addressed.
Cells 2019, 8(12), 1530;
Received: 22 October 2019 / Revised: 19 November 2019 / Accepted: 23 November 2019 / Published: 27 November 2019
(This article belongs to the Special Issue Stem Cell Research on Cardiology)
Cardiovascular diseases remain the leading cause of death in the developed world, accounting for more than 30% of all deaths. In a large proportion of these patients, acute myocardial infarction is usually the first manifestation, which might further progress to heart failure. In addition, the human heart displays a low regenerative capacity, leading to a loss of cardiomyocytes and persistent tissue scaring, which entails a morbid pathologic sequela. Novel therapeutic approaches are urgently needed. Stem cells, such as induced pluripotent stem cells or embryonic stem cells, exhibit great potential for cell-replacement therapy and an excellent tool for disease modeling, as well as pharmaceutical screening of novel drugs and their cardiac side effects. This review article covers not only the origin of stem cells but tries to summarize their translational potential, as well as potential risks and clinical translation. View Full-Text
Keywords: iPSC; PSC; ESC; cardiovascular disease; regeneration iPSC; PSC; ESC; cardiovascular disease; regeneration
Show Figures

Graphical abstract

MDPI and ACS Style

Samak, M.; Hinkel, R. Stem Cells in Cardiovascular Medicine: Historical Overview and Future Prospects. Cells 2019, 8, 1530.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop