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MicroRNA Signatures as Future Biomarkers for Diagnosis of Diabetes States

1
Islet Cell Laboratory, Baylor Scott and White Research Institute, 3434 Live Oak Street, Dallas, TX 75204, USA
2
Department of Biomedical Studies, Baylor University, 1301 S. University Parks Dr., Waco, TX 75706, USA
3
Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, 3410 Worth St., Suite 950, Dallas, TX 75246, USA
*
Author to whom correspondence should be addressed.
Cells 2019, 8(12), 1533; https://doi.org/10.3390/cells8121533
Received: 31 October 2019 / Revised: 22 November 2019 / Accepted: 24 November 2019 / Published: 28 November 2019
(This article belongs to the Special Issue microRNA as Biomarker)
Diabetes results from the inability of pancreatic islets to maintain blood glucose concentrations within a normal physiological range. Clinical features are usually not observed until islets begin to fail and irreversible damage has occurred. Diabetes is generally diagnosed based on elevated glucose, which does not distinguish between type 1 and 2 diabetes. Thus, new diagnostic approaches are needed to detect different modes of diabetes before manifestation of disease. During prediabetes (pre-DM), islets undergo stress and release micro (mi) RNAs. Here, we review studies that have measured and tracked miRNAs in the blood for those with recent-onset or longstanding type 1 diabetes, obesity, pre-diabetes, type 2 diabetes, and gestational diabetes. We summarize the findings on miRNA signatures with the potential to stage progression of different modes of diabetes. Advances in identifying selective biomarker signatures may aid in early detection and classification of diabetic conditions and treatments to prevent and reverse diabetes. View Full-Text
Keywords: diabetes; biomarker; miRNA; islet diabetes; biomarker; miRNA; islet
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MDPI and ACS Style

Vasu, S.; Kumano, K.; Darden, C.M.; Rahman, I.; Lawrence, M.C.; Naziruddin, B. MicroRNA Signatures as Future Biomarkers for Diagnosis of Diabetes States. Cells 2019, 8, 1533.

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