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The Many Roles of Cell Adhesion Molecules in Hepatic Fibrosis

Pharmazentrum Frankfurt/ZAFES, Goethe University Hospital Frankfurt, 60590 Frankfurt am Main, Germany
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Cells 2019, 8(12), 1503; https://doi.org/10.3390/cells8121503
Received: 30 October 2019 / Revised: 17 November 2019 / Accepted: 18 November 2019 / Published: 24 November 2019
Fibrogenesis is a progressive scarring event resulting from disrupted regular wound healing due to repeated tissue injury and can end in organ failure, like in liver cirrhosis. The protagonists in this process, either liver-resident cells or patrolling leukocytes attracted to the site of tissue damage, interact with each other by soluble factors but also by direct cell–cell contact mediated by cell adhesion molecules. Since cell adhesion molecules also support binding to the extracellular matrix, they represent excellent biosensors, which allow cells to modulate their behavior based on changes in the surrounding microenvironment. In this review, we focus on selectins, cadherins, integrins and members of the immunoglobulin superfamily of adhesion molecules as well as some non-classical cell adhesion molecules in the context of hepatic fibrosis. We describe their liver-specific contributions to leukocyte recruitment, cell differentiation and survival, matrix remodeling or angiogenesis and touch on their suitability as targets in antifibrotic therapies. View Full-Text
Keywords: cell adhesion; liver fibrosis; selectin; integrin; cadherin; immunoglobulin superfamily; junctional adhesion molecule; non-classical adhesion molecule; antifibrotic therapy cell adhesion; liver fibrosis; selectin; integrin; cadherin; immunoglobulin superfamily; junctional adhesion molecule; non-classical adhesion molecule; antifibrotic therapy
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Hintermann, E.; Christen, U. The Many Roles of Cell Adhesion Molecules in Hepatic Fibrosis. Cells 2019, 8, 1503.

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