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Correction published on 27 June 2024, see Cells 2024, 13(13), 1111.
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Article

TCTP from Loxosceles Intermedia (Brown Spider) Venom Contributes to the Allergic and Inflammatory Response of Cutaneous Loxoscelism

by
Marianna Boia-Ferreira
1,
Kamila G. Moreno
1,
Alana B. C. Basílio
1,
Lucas P. da Silva
1,
Larissa Vuitika
1,
Bruna Soley
2,
Ana Carolina M. Wille
3,
Lucélia Donatti
1,
Katia C. Barbaro
4,
Olga M. Chaim
1,5,
Luiza Helena Gremski
1,
Silvio S. Veiga
1 and
Andrea Senff-Ribeiro
1,*
1
Department of Cell Biology, Federal University of Paraná, Curitiba 81531-980, PR, Brazil
2
Department of Pharmacology, Federal University of Paraná, Curitiba 81531-980, PR, Brazil
3
Department of Structural and Molecular Biology, State University of Ponta Grossa, Ponta Grossa 84030-900, PR, Brazil
4
Laboratory of Immunopathology, Butantan Institute, São Paulo 05503-900, SP, Brazil
5
Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
*
Author to whom correspondence should be addressed.
Cells 2019, 8(12), 1489; https://doi.org/10.3390/cells8121489
Submission received: 22 August 2019 / Revised: 7 November 2019 / Accepted: 10 November 2019 / Published: 22 November 2019 / Corrected: 27 June 2024
(This article belongs to the Special Issue Role of TCTP in Cell Biological and Disease Processes)
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Abstract

LiTCTP is a toxin from the Translationally Controlled Tumor Protein (TCTP) family identified in Loxosceles brown spider venoms. These proteins are known as histamine-releasing factors (HRF). TCTPs participate in allergic and anaphylactic reactions, which suggest their potential role as therapeutic targets. The histaminergic effect of TCTP is related to its pro-inflammatory functions. An initial characterization of LiTCTP in animal models showed that this toxin can increase the microvascular permeability of skin vessels and induce paw edema in a dose-dependent manner. We evaluated the role of LiTCTP in vitro and in vivo in the inflammatory and allergic aspects that undergo the biological responses observed in Loxoscelism, the clinical condition after an accident with Loxosceles spiders. Our results showed LiTCTP recombinant toxin (LiRecTCTP) as an essential synergistic factor for the dermonecrotic toxin actions (LiRecDT1, known as the main toxin in the pathophysiology of Loxoscelism), revealing its contribution to the exacerbated inflammatory response clinically observed in envenomated patients.
Keywords: Loxosceles; brown spider; TCTP; venom; toxin; HRF Loxosceles; brown spider; TCTP; venom; toxin; HRF

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MDPI and ACS Style

Boia-Ferreira, M.; Moreno, K.G.; Basílio, A.B.C.; da Silva, L.P.; Vuitika, L.; Soley, B.; Wille, A.C.M.; Donatti, L.; Barbaro, K.C.; Chaim, O.M.; et al. TCTP from Loxosceles Intermedia (Brown Spider) Venom Contributes to the Allergic and Inflammatory Response of Cutaneous Loxoscelism. Cells 2019, 8, 1489. https://doi.org/10.3390/cells8121489

AMA Style

Boia-Ferreira M, Moreno KG, Basílio ABC, da Silva LP, Vuitika L, Soley B, Wille ACM, Donatti L, Barbaro KC, Chaim OM, et al. TCTP from Loxosceles Intermedia (Brown Spider) Venom Contributes to the Allergic and Inflammatory Response of Cutaneous Loxoscelism. Cells. 2019; 8(12):1489. https://doi.org/10.3390/cells8121489

Chicago/Turabian Style

Boia-Ferreira, Marianna, Kamila G. Moreno, Alana B. C. Basílio, Lucas P. da Silva, Larissa Vuitika, Bruna Soley, Ana Carolina M. Wille, Lucélia Donatti, Katia C. Barbaro, Olga M. Chaim, and et al. 2019. "TCTP from Loxosceles Intermedia (Brown Spider) Venom Contributes to the Allergic and Inflammatory Response of Cutaneous Loxoscelism" Cells 8, no. 12: 1489. https://doi.org/10.3390/cells8121489

APA Style

Boia-Ferreira, M., Moreno, K. G., Basílio, A. B. C., da Silva, L. P., Vuitika, L., Soley, B., Wille, A. C. M., Donatti, L., Barbaro, K. C., Chaim, O. M., Gremski, L. H., Veiga, S. S., & Senff-Ribeiro, A. (2019). TCTP from Loxosceles Intermedia (Brown Spider) Venom Contributes to the Allergic and Inflammatory Response of Cutaneous Loxoscelism. Cells, 8(12), 1489. https://doi.org/10.3390/cells8121489

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