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Open AccessArticle

TCTP from Loxosceles Intermedia (Brown Spider) Venom Contributes to the Allergic and Inflammatory Response of Cutaneous Loxoscelism

1
Department of Cell Biology, Federal University of Paraná, Curitiba 81531-980, PR, Brazil
2
Department of Pharmacology, Federal University of Paraná, Curitiba 81531-980, PR, Brazil
3
Department of Structural and Molecular Biology, State University of Ponta Grossa, Ponta Grossa 84030-900, PR, Brazil
4
Laboratory of Immunopathology, Butantan Institute, São Paulo 05503-900, SP, Brazil
5
Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
*
Author to whom correspondence should be addressed.
Cells 2019, 8(12), 1489; https://doi.org/10.3390/cells8121489
Received: 22 August 2019 / Revised: 7 November 2019 / Accepted: 10 November 2019 / Published: 22 November 2019
(This article belongs to the Special Issue Role of TCTP in Cell Biological and Disease Processes)
LiTCTP is a toxin from the Translationally Controlled Tumor Protein (TCTP) family identified in Loxosceles brown spider venoms. These proteins are known as histamine-releasing factors (HRF). TCTPs participate in allergic and anaphylactic reactions, which suggest their potential role as therapeutic targets. The histaminergic effect of TCTP is related to its pro-inflammatory functions. An initial characterization of LiTCTP in animal models showed that this toxin can increase the microvascular permeability of skin vessels and induce paw edema in a dose-dependent manner. We evaluated the role of LiTCTP in vitro and in vivo in the inflammatory and allergic aspects that undergo the biological responses observed in Loxoscelism, the clinical condition after an accident with Loxosceles spiders. Our results showed LiTCTP recombinant toxin (LiRecTCTP) as an essential synergistic factor for the dermonecrotic toxin actions (LiRecDT1, known as the main toxin in the pathophysiology of Loxoscelism), revealing its contribution to the exacerbated inflammatory response clinically observed in envenomated patients. View Full-Text
Keywords: Loxosceles; brown spider; TCTP; venom; toxin; HRF Loxosceles; brown spider; TCTP; venom; toxin; HRF
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Boia-Ferreira, M.; Moreno, K.G.; Basílio, A.B.C.; da Silva, L.P.; Vuitika, L.; Soley, B.; Wille, A.C.M.; Donatti, L.; Barbaro, K.C.; Chaim, O.M.; Gremski, L.H.; Veiga, S.S.; Senff-Ribeiro, A. TCTP from Loxosceles Intermedia (Brown Spider) Venom Contributes to the Allergic and Inflammatory Response of Cutaneous Loxoscelism. Cells 2019, 8, 1489.

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