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Open AccessReview

Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues

1
Nutrition, Dietetics and Food Science Department, Brigham Young University, Provo, Utah 84602, USA
2
Microbiology and Molecular Biology Department, Brigham Young University, Provo, Utah 84602, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cells 2019, 8(11), 1373; https://doi.org/10.3390/cells8111373
Received: 30 September 2019 / Revised: 24 October 2019 / Accepted: 30 October 2019 / Published: 1 November 2019
(This article belongs to the Special Issue Functions of Nuclear Receptors)
The Nr4a family of nuclear hormone receptors is composed of three members—Nr4a1/Nur77, Nr4a2/Nurr1 and Nr4a3/Nor1. While currently defined as ligandless, these transcription factors have been shown to regulate varied processes across a host of tissues. Of particular interest, the Nr4a family impinge, in a tissue dependent fashion, on cellular proliferation, apoptosis and fuel utilization. The regulation of these processes occurs through both nuclear and non-genomic pathways. The purpose of this review is to provide a balanced perspective of the tissue specific and Nr4a family member specific, effects on cellular proliferation, apoptosis and fuel utilization.
Keywords: Nr4a1; Nr4a2; Nr4a3; nuclear hormone receptors; metabolism; fuel utilization; proliferation; apoptosis Nr4a1; Nr4a2; Nr4a3; nuclear hormone receptors; metabolism; fuel utilization; proliferation; apoptosis
MDPI and ACS Style

Herring, J.A.; Elison, W.S.; Tessem, J.S. Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues. Cells 2019, 8, 1373.

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