Next Article in Journal
MicroRNAs in Inflammatory Heart Diseases and Sepsis-Induced Cardiac Dysfunction: A Potential Scope for the Future?
Previous Article in Journal
Functions and Implications of Autophagy in Colon Cancer
Open AccessArticle

BAP31 Inhibits Cell Adaptation to ER Stress Conditions, Negatively Regulating Autophagy Induction by Interaction with STX17

by Kayo Machihara 1,2,† and Takushi Namba 1,3,*,†
1
Research and Education Faculty, Multidisciplinary Science Cluster, Interdisciplinary Science Unit, Kochi University, Kohasu Oko-cho Nankoku-shi, Kochi 783-8505, Japan
2
Graduate School of Medicine, Kochi University, Nankoku 783-8502, Japan
3
Department of Marine Resource Science, Faculty of Agriculture and Marine Science, Kochi University, Nankoku 783-8502, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cells 2019, 8(11), 1350; https://doi.org/10.3390/cells8111350
Received: 13 September 2019 / Revised: 25 October 2019 / Accepted: 29 October 2019 / Published: 30 October 2019
(This article belongs to the Section Cell Signaling and Regulated Cell Death)
Cancer cells modulate their metabolism to proliferate and survive under the metabolic stress condition, which is known as endoplasmic reticulum (ER) stress. Therefore, cancer cells should suppress ER stress-mediated cell death and induce autophagy—which recycles metabolites to provide energy and new macromolecules. In this study, we demonstrate that the ER membrane protein BAP31 acts to suppress adaptation to ER stress conditions, induce cell death, and suppress autophagy by forming a BAP31-STX17 protein complex. The loss of BAP31 stimulates tumor growth in metabolic stress conditions in vivo and enhances invasion activity. Therefore, BAP31 stimulates cell death and inhibits autophagy, and it can be considered a novel tumor suppressor factor that acts by preventing ER stress adaptation. View Full-Text
Keywords: ER stress; autophagy; BAP31; STX17; tumor suppression; stress adaptation ER stress; autophagy; BAP31; STX17; tumor suppression; stress adaptation
Show Figures

Figure 1

MDPI and ACS Style

Machihara, K.; Namba, T. BAP31 Inhibits Cell Adaptation to ER Stress Conditions, Negatively Regulating Autophagy Induction by Interaction with STX17. Cells 2019, 8, 1350.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop