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Cells
Volume 8
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10.3390/cells8111305
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Review

Articular Cartilage Regeneration in Osteoarthritis

by
Livia Roseti
1,
Giovanna Desando
1,
Carola Cavallo
1,*,
Mauro Petretta
1,2 and
Brunella Grigolo
1
1
Laboratorio RAMSES, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136 Bologna, Italy
2
RegenHU LTD, Z.I. Du Vivier 22, CH-1690 Villaz-St-Pierre, Switzerland
*
Author to whom correspondence should be addressed.
Cells 2019, 8(11), 1305; https://doi.org/10.3390/cells8111305
Submission received: 13 September 2019 / Revised: 18 October 2019 / Accepted: 21 October 2019 / Published: 23 October 2019
(This article belongs to the Special Issue Cell Biological Techniques and Cell-Biomaterial Interactions)
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Abstract

There has been considerable advancement over the last few years in the treatment of osteoarthritis, common chronic disease and a major cause of disability in older adults. In this pathology, the entire joint is involved and the regeneration of articular cartilage still remains one of the main challenges, particularly in an actively inflammatory environment. The recent strategies for osteoarthritis treatment are based on the use of different therapeutic solutions such as cell and gene therapies and tissue engineering. In this review, we provide an overview of current regenerative strategies highlighting the pros and cons, challenges and opportunities, and we try to identify areas where future work should be focused in order to advance this field.
Keywords: osteoarthritis; cartilage; cell-based therapy; tissue-based therapy; gene therapy osteoarthritis; cartilage; cell-based therapy; tissue-based therapy; gene therapy

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MDPI and ACS Style

Roseti, L.; Desando, G.; Cavallo, C.; Petretta, M.; Grigolo, B. Articular Cartilage Regeneration in Osteoarthritis. Cells 2019, 8, 1305. https://doi.org/10.3390/cells8111305

AMA Style

Roseti L, Desando G, Cavallo C, Petretta M, Grigolo B. Articular Cartilage Regeneration in Osteoarthritis. Cells. 2019; 8(11):1305. https://doi.org/10.3390/cells8111305

Chicago/Turabian Style

Roseti, Livia, Giovanna Desando, Carola Cavallo, Mauro Petretta, and Brunella Grigolo. 2019. "Articular Cartilage Regeneration in Osteoarthritis" Cells 8, no. 11: 1305. https://doi.org/10.3390/cells8111305

APA Style

Roseti, L., Desando, G., Cavallo, C., Petretta, M., & Grigolo, B. (2019). Articular Cartilage Regeneration in Osteoarthritis. Cells, 8(11), 1305. https://doi.org/10.3390/cells8111305

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