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Open AccessReview

Stem Cell-Derived Extracellular Vesicles and Kidney Regeneration

1
Department of Medical Sciences, University of Turin, via Nizza 52, 10126 Torino, Italy
2
Department of Molecular Biotechnology and Health Sciences, University of Turin, via Nizza 52, 10126 Torino, Italy
3
Maria Pia Hospital, 10132 Turin, Italy
*
Author to whom correspondence should be addressed.
Cells 2019, 8(10), 1240; https://doi.org/10.3390/cells8101240
Received: 20 September 2019 / Revised: 10 October 2019 / Accepted: 11 October 2019 / Published: 11 October 2019
(This article belongs to the Special Issue Advances in Stem Cells and Regenerative Medicine)
Extracellular vesicles (EVs) are membranous vesicles containing active proteins, lipids, and different types of genetic material such as miRNAs, mRNAs, and DNAs related to the characteristics of the originating cell. They possess a distinctive capacity to communicate over long distances. EVs have been involved in the modulation of several pathophysiological conditions and, more importantly, stem cell-derived EVs appear as a new promising therapeutic option. In fact, several reports provide convincing evidence of the regenerative potential of EVs released by stem cells and, in particular, mesenchymal stromal cells (MSCs) in different kidney injury models. Described mechanisms involve the reprogramming of injured cells, cell proliferation and angiogenesis, and inhibition of cell apoptosis and inflammation. Besides, the therapeutic use of MSC-EVs in clinical trials is under investigation. This review will focus on MSC-EV applications in preclinical models of acute and chronic renal damage including recent data on their use in kidney transplant conditioning. Moreover, ongoing clinical trials are described. Finally, new strategies to broaden and enhance EV therapeutic efficacy by engineering are discussed. View Full-Text
Keywords: AKI; CKD; exosomes; regenerative medicine; renal injury AKI; CKD; exosomes; regenerative medicine; renal injury
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MDPI and ACS Style

Grange, C.; Skovronova, R.; Marabese, F.; Bussolati, B. Stem Cell-Derived Extracellular Vesicles and Kidney Regeneration. Cells 2019, 8, 1240.

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