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Open AccessReview

The Hemocompatibility of Nanoparticles: A Review of Cell–Nanoparticle Interactions and Hemostasis

Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Science, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South Africa
Author to whom correspondence should be addressed.
Cells 2019, 8(10), 1209;
Received: 14 September 2019 / Revised: 1 October 2019 / Accepted: 3 October 2019 / Published: 7 October 2019
(This article belongs to the Special Issue Cell Biological Techniques and Cell-Biomaterial Interactions)
Understanding cell–nanoparticle interactions is critical to developing effective nanosized drug delivery systems. Nanoparticles have already advanced the treatment of several challenging conditions including cancer and human immunodeficiency virus (HIV), yet still hold the potential to improve drug delivery to elusive target sites. Even though most nanoparticles will encounter blood at a certain stage of their transport through the body, the interactions between nanoparticles and blood cells is still poorly understood and the importance of evaluating nanoparticle hemocompatibility is vastly understated. In contrast to most review articles that look at the interference of nanoparticles with the intricate coagulation cascade, this review will explore nanoparticle hemocompatibility from a cellular angle. The most important functions of the three cellular components of blood, namely erythrocytes, platelets and leukocytes, in hemostasis are highlighted. The potential deleterious effects that nanoparticles can have on these cells are discussed and insight is provided into some of the complex mechanisms involved in nanoparticle–blood cell interactions. Throughout the review, emphasis is placed on the importance of undertaking thorough, all-inclusive hemocompatibility studies on newly engineered nanoparticles to facilitate their translation into clinical application. View Full-Text
Keywords: hemocompatibility; nanoparticles; erythrocytes; platelets; leukocytes hemocompatibility; nanoparticles; erythrocytes; platelets; leukocytes
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MDPI and ACS Style

de la Harpe, K.M.; Kondiah, P.P.D.; Choonara, Y.E.; Marimuthu, T.; du Toit, L.C.; Pillay, V. The Hemocompatibility of Nanoparticles: A Review of Cell–Nanoparticle Interactions and Hemostasis. Cells 2019, 8, 1209.

AMA Style

de la Harpe KM, Kondiah PPD, Choonara YE, Marimuthu T, du Toit LC, Pillay V. The Hemocompatibility of Nanoparticles: A Review of Cell–Nanoparticle Interactions and Hemostasis. Cells. 2019; 8(10):1209.

Chicago/Turabian Style

de la Harpe, Kara M.; Kondiah, Pierre P.D.; Choonara, Yahya E.; Marimuthu, Thashree; du Toit, Lisa C.; Pillay, Viness. 2019. "The Hemocompatibility of Nanoparticles: A Review of Cell–Nanoparticle Interactions and Hemostasis" Cells 8, no. 10: 1209.

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