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Review

Insights into Biological Role of LncRNAs in Epithelial-Mesenchymal Transition

by 1,2,†, 3,4,†, 5, 5, 1,2, 4,*, 1,2 and 1,2,*
1
School of Basic Medicine, Health Science Center, Yangtze University, Nanhuan Road, Jingzhou, Hubei 434023, China
2
The First School of Clinical Medicine, Health Science Center, Yangtze University, 1 Nanhuan Road, Jingzhou, Hubei 434023, China
3
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore
4
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore
5
Singapore Nuclear Research and Safety Initiative, National University of Singapore, Sinagpore 138602, Singapore
*
Authors to whom correspondence should be addressed.
These authors share equal contribution.
Cells 2019, 8(10), 1178; https://doi.org/10.3390/cells8101178
Received: 22 August 2019 / Revised: 24 September 2019 / Accepted: 27 September 2019 / Published: 30 September 2019
Long non-coding RNAs (lncRNAs) are versatile regulators of gene expression and play crucial roles in diverse biological processes. Epithelial-mesenchymal transition (EMT) is a cellular program that drives plasticity during embryogenesis, wound healing, and malignant progression. Increasing evidence shows that lncRNAs orchestrate multiple cellular processes by modulating EMT in diverse cell types. Dysregulated lncRNAs that can impact epithelial plasticity by affecting different EMT markers and target genes have been identified. However, our understanding of the landscape of lncRNAs important in EMT is far from complete. Here, we summarize recent findings on the mechanisms and roles of lncRNAs in EMT and elaborate on how lncRNAs can modulate EMT by interacting with RNA, DNA, or proteins in epigenetic, transcriptional, and post-transcriptional regulation. This review also highlights significant EMT pathways that may be altered by diverse lncRNAs, thereby suggesting their therapeutic potential. View Full-Text
Keywords: long non-coding RNA; epithelial-mesenchymal transition (EMT); cancer; signaling pathways long non-coding RNA; epithelial-mesenchymal transition (EMT); cancer; signaling pathways
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MDPI and ACS Style

Cheng, J.-T.; Wang, L.; Wang, H.; Tang, F.-R.; Cai, W.-Q.; Sethi, G.; Xin, H.-W.; Ma, Z. Insights into Biological Role of LncRNAs in Epithelial-Mesenchymal Transition. Cells 2019, 8, 1178. https://doi.org/10.3390/cells8101178

AMA Style

Cheng J-T, Wang L, Wang H, Tang F-R, Cai W-Q, Sethi G, Xin H-W, Ma Z. Insights into Biological Role of LncRNAs in Epithelial-Mesenchymal Transition. Cells. 2019; 8(10):1178. https://doi.org/10.3390/cells8101178

Chicago/Turabian Style

Cheng, Jun-Ting, Lingzhi Wang, Hong Wang, Feng-Ru Tang, Wen-Qi Cai, Gautam Sethi, Hong-Wu Xin, and Zhaowu Ma. 2019. "Insights into Biological Role of LncRNAs in Epithelial-Mesenchymal Transition" Cells 8, no. 10: 1178. https://doi.org/10.3390/cells8101178

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