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Cells 2019, 8(1), 13;

The Fate of Fusions

Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA
Received: 28 November 2018 / Revised: 21 December 2018 / Accepted: 26 December 2018 / Published: 29 December 2018
(This article belongs to the Special Issue Tumor-Cell Fusion—The Dark Matter Phenomenon)
Full-Text   |   PDF [197 KB, uploaded 29 December 2018]


The concept of leukocyte-tumor cell fusion as a significant driver of cancer progression has been around a long time, and has garnered growing support over the last several years. The underlying idea seems quite simple and attractive: Fusion of tumor cells (with their inherent genetic instability) with leukocytes, particularly macrophages, could produce hybrids with high invasive capabilities, greatly facilitating their metastatic dissemination, while potentially accelerating tumor cell heterogeneity. While there are a number of attractive features with this story on the surface, the various studies seem to leave us with a conundrum, namely, what is the fate of such fusions? View Full-Text
Keywords: macrophage-tumor cell fusions; MTFs; CTCs; metastasis; metastasis-initiating cells; MICs macrophage-tumor cell fusions; MTFs; CTCs; metastasis; metastasis-initiating cells; MICs
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Clawson, G. The Fate of Fusions. Cells 2019, 8, 13.

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