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Cells 2018, 7(3), 18;

Miro—Working beyond Mitochondria and Microtubules

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117597, Singapore
Received: 5 February 2018 / Revised: 2 March 2018 / Accepted: 3 March 2018 / Published: 4 March 2018
PDF [628 KB, uploaded 4 March 2018]


The small GTPase Miro is best known for its regulation of mitochondrial movement by engaging with the microtubule-based motor proteins kinesin and dynein. Very recent findings have now showed that Miro also targets peroxisomes and regulates microtubule-dependent peroxisome motility. Moreover, Miro recruits and stabilizes the myosin motor Myo19 at the mitochondria to enable actin-based mitochondria movement, which is important for mitochondrial segregation during mitosis. Miro thus has much broader functions that previously known, and these new findings may have important implications on disease pathology. View Full-Text
Keywords: Mitochondrial Rho (Miro); mitochondria; peroxisome; microtubules; actin Mitochondrial Rho (Miro); mitochondria; peroxisome; microtubules; actin

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Tang, B.L. Miro—Working beyond Mitochondria and Microtubules. Cells 2018, 7, 18.

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