Next Article in Journal
The Effect of Ethanol on Telomere Dynamics and Regulation in Human Cells
Previous Article in Journal
Extracellular Vesicles and Matrix Remodeling Enzymes: The Emerging Roles in Extracellular Matrix Remodeling, Progression of Diseases and Tissue Repair
Previous Article in Special Issue
Challenges of Decoding Transcription Factor Dynamics in Terms of Gene Regulation
Open AccessReview

Real-Time Determination of the Cell-Cycle Position of Individual Cells within Live Tumors Using FUCCI Cell-Cycle Imaging

by Shuya Yano 1,3 and Robert M. Hoffman 1,2,*
1
AntiCancer, Inc., 7917 Ostrow street, San Diego, CA 92111, USA
2
Department of Surgery, University of California San Diego, La Jolla, CA 92111, USA
3
Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-0016, Japan
*
Author to whom correspondence should be addressed.
Cells 2018, 7(10), 168; https://doi.org/10.3390/cells7100168
Received: 31 July 2018 / Revised: 3 October 2018 / Accepted: 9 October 2018 / Published: 14 October 2018
(This article belongs to the Special Issue Innovative Methods to Monitor Single Live Cells)
Most cytotoxic agents have limited efficacy for solid cancers. Cell-cycle phase analysis at the single-cell level in solid tumors has shown that the majority of cancer cells in tumors is not cycling and is therefore resistant to cytotoxic chemotherapy. Intravital cell-cycle imaging within tumors demonstrated the cell-cycle position and distribution of cancer cells within a tumor, and cell-cycle dynamics during chemotherapy. Understanding cell-cycle dynamics within tumors should provide important insights into novel treatment strategies. View Full-Text
Keywords: cell cycle; fluorescent proteins; FUCCI; imaging cell cycle; fluorescent proteins; FUCCI; imaging
Show Figures

Graphical abstract

MDPI and ACS Style

Yano, S.; Hoffman, R.M. Real-Time Determination of the Cell-Cycle Position of Individual Cells within Live Tumors Using FUCCI Cell-Cycle Imaging. Cells 2018, 7, 168.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop