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Cells 2018, 7(10), 168; https://doi.org/10.3390/cells7100168

Real-Time Determination of the Cell-Cycle Position of Individual Cells within Live Tumors Using FUCCI Cell-Cycle Imaging

1
AntiCancer, Inc., 7917 Ostrow street, San Diego, CA 92111, USA
2
Department of Surgery, University of California San Diego, La Jolla, CA 92111, USA
3
Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-0016, Japan
*
Author to whom correspondence should be addressed.
Received: 31 July 2018 / Revised: 3 October 2018 / Accepted: 9 October 2018 / Published: 14 October 2018
(This article belongs to the Special Issue Innovative Methods to Monitor Single Live Cells)
Full-Text   |   PDF [3821 KB, uploaded 14 October 2018]   |  

Abstract

Most cytotoxic agents have limited efficacy for solid cancers. Cell-cycle phase analysis at the single-cell level in solid tumors has shown that the majority of cancer cells in tumors is not cycling and is therefore resistant to cytotoxic chemotherapy. Intravital cell-cycle imaging within tumors demonstrated the cell-cycle position and distribution of cancer cells within a tumor, and cell-cycle dynamics during chemotherapy. Understanding cell-cycle dynamics within tumors should provide important insights into novel treatment strategies. View Full-Text
Keywords: cell cycle; fluorescent proteins; FUCCI; imaging cell cycle; fluorescent proteins; FUCCI; imaging
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Yano, S.; Hoffman, R.M. Real-Time Determination of the Cell-Cycle Position of Individual Cells within Live Tumors Using FUCCI Cell-Cycle Imaging. Cells 2018, 7, 168.

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