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The Regulation of NF-κB Subunits by Phosphorylation

Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK
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Academic Editor: Alexander E. Kalyuzhny
Cells 2016, 5(1), 12; https://doi.org/10.3390/cells5010012
Received: 26 February 2016 / Revised: 9 March 2016 / Accepted: 14 March 2016 / Published: 18 March 2016
(This article belongs to the Special Issue Cellular and Molecular Biology of NF-κB)
The NF-κB transcription factor is the master regulator of the inflammatory response and is essential for the homeostasis of the immune system. NF-κB regulates the transcription of genes that control inflammation, immune cell development, cell cycle, proliferation, and cell death. The fundamental role that NF-κB plays in key physiological processes makes it an important factor in determining health and disease. The importance of NF-κB in tissue homeostasis and immunity has frustrated therapeutic approaches aimed at inhibiting NF-κB activation. However, significant research efforts have revealed the crucial contribution of NF-κB phosphorylation to controlling NF-κB directed transactivation. Importantly, NF-κB phosphorylation controls transcription in a gene-specific manner, offering new opportunities to selectively target NF-κB for therapeutic benefit. This review will focus on the phosphorylation of the NF-κB subunits and the impact on NF-κB function. View Full-Text
Keywords: NF-κB; phosphorylation; kinase; transcription factor NF-κB; phosphorylation; kinase; transcription factor
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MDPI and ACS Style

Christian, F.; Smith, E.L.; Carmody, R.J. The Regulation of NF-κB Subunits by Phosphorylation. Cells 2016, 5, 12. https://doi.org/10.3390/cells5010012

AMA Style

Christian F, Smith EL, Carmody RJ. The Regulation of NF-κB Subunits by Phosphorylation. Cells. 2016; 5(1):12. https://doi.org/10.3390/cells5010012

Chicago/Turabian Style

Christian, Frank; Smith, Emma L.; Carmody, Ruaidhrí J. 2016. "The Regulation of NF-κB Subunits by Phosphorylation" Cells 5, no. 1: 12. https://doi.org/10.3390/cells5010012

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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