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Review

Cyclic GMP and Cilia Motility

by 1,2,3
1
VA Nebraska-Western Iowa Health Care System, Research Service, Department of Veterans Affairs Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA
2
Department of Environmental, Agricultural, and Occupational Health, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198-5910, USA
3
Pulmonary, Critical Care, Sleep & Allergy Division, Department of Internal Medicine, 985910 Nebraska Medical Center, Omaha, NE 68198-5910, USA 
Academic Editors: Gang Dong and William Tsang
Cells 2015, 4(3), 315-330; https://doi.org/10.3390/cells4030315
Received: 21 May 2015 / Revised: 6 July 2015 / Accepted: 24 July 2015 / Published: 31 July 2015
(This article belongs to the Special Issue Cilia and Flagella: Biogenesis and Function)
Motile cilia of the lungs respond to environmental challenges by increasing their ciliary beat frequency in order to enhance mucociliary clearance as a fundamental tenant of innate defense. One important second messenger in transducing the regulable nature of motile cilia is cyclic guanosine 3′,5′-monophosphate (cGMP). In this review, the history of cGMP action is presented and a survey of the existing data addressing cGMP action in ciliary motility is presented. Nitric oxide (NO)-mediated regulation of cGMP in ciliated cells is presented in the context of alcohol-induced cilia function and dysfunction. View Full-Text
Keywords: cilia; cGMP; signal transduction; history; review cilia; cGMP; signal transduction; history; review
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MDPI and ACS Style

Wyatt, T.A. Cyclic GMP and Cilia Motility. Cells 2015, 4, 315-330. https://doi.org/10.3390/cells4030315

AMA Style

Wyatt TA. Cyclic GMP and Cilia Motility. Cells. 2015; 4(3):315-330. https://doi.org/10.3390/cells4030315

Chicago/Turabian Style

Wyatt, Todd A. 2015. "Cyclic GMP and Cilia Motility" Cells 4, no. 3: 315-330. https://doi.org/10.3390/cells4030315

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