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Cells 2014, 3(2), 199-235;

Role of Receptor Tyrosine Kinases and Their Ligands in Glioblastoma

Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Elche (Alicante) 03202, Spain
División de Neurooncología, Instituto Biodonostia, San Sebastián (Guipuzkoa) 20014, Spain
Unidad de Investigación, Hospital General Universitario de Elche, Elche (Alicante) 03203, Spain
Unidad AECC de Investigación Traslacional en Cáncer, Hospital Clínico Universitario Virgen de la Arrixaca, Instituto Murciano de Investigación Biosanitaria, Murcia 30120, Spain
Author to whom correspondence should be addressed.
Received: 18 December 2013 / Revised: 12 March 2014 / Accepted: 21 March 2014 / Published: 4 April 2014
(This article belongs to the Special Issue Receptor Tyrosine Kinases)
Full-Text   |   PDF [398 KB, uploaded 4 April 2014]   |  


Glioblastoma multiforme is the most frequent, aggressive and fatal type of brain tumor. Glioblastomas are characterized by their infiltrating nature, high proliferation rate and resistance to chemotherapy and radiation. Recently, oncologic therapy experienced a rapid evolution towards “targeted therapy,” which is the employment of drugs directed against particular targets that play essential roles in proliferation, survival and invasiveness of cancer cells. A number of molecules involved in signal transduction pathways are used as molecular targets for the treatment of various tumors. In fact, inhibitors of these molecules have already entered the clinic or are undergoing clinical trials. Cellular receptors are clear examples of such targets and in the case of glioblastoma multiforme, some of these receptors and their ligands have become relevant. In this review, the importance of glioblastoma multiforme in signaling pathways initiated by extracellular tyrosine kinase receptors such as EGFR, PDGFR and IGF-1R will be discussed. We will describe their ligands, family members, structure, activation mechanism, downstream molecules, as well as the interaction among these pathways. Lastly, we will provide an up-to-date review of the current targeted therapies in cancer, in particular glioblastoma that employ inhibitors of these pathways and their benefits. View Full-Text
Keywords: RTK; EGFR; PDGFR; IGF-1R; glioblastoma multiforme RTK; EGFR; PDGFR; IGF-1R; glioblastoma multiforme

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Carrasco-García, E.; Saceda, M.; Martínez-Lacaci, I. Role of Receptor Tyrosine Kinases and Their Ligands in Glioblastoma. Cells 2014, 3, 199-235.

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