Next Article in Journal
Inflammatory and Bone Remodeling Responses to the Cytolethal Distending Toxins
Next Article in Special Issue
Mechanisms of Activation of Receptor Tyrosine Kinases: Monomers or Dimers
Previous Article in Journal
Yeast Irc22 Is a Novel Dsk2-Interacting Protein that Is Involved in Salt Tolerance
Previous Article in Special Issue
Flotillins in Receptor Tyrosine Kinase Signaling and Cancer
Open AccessReview

Role of Receptor Tyrosine Kinases and Their Ligands in Glioblastoma

1
Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Elche (Alicante) 03202, Spain
2
División de Neurooncología, Instituto Biodonostia, San Sebastián (Guipuzkoa) 20014, Spain
3
Unidad de Investigación, Hospital General Universitario de Elche, Elche (Alicante) 03203, Spain
4
Unidad AECC de Investigación Traslacional en Cáncer, Hospital Clínico Universitario Virgen de la Arrixaca, Instituto Murciano de Investigación Biosanitaria, Murcia 30120, Spain
*
Author to whom correspondence should be addressed.
Cells 2014, 3(2), 199-235; https://doi.org/10.3390/cells3020199
Received: 18 December 2013 / Revised: 12 March 2014 / Accepted: 21 March 2014 / Published: 4 April 2014
(This article belongs to the Special Issue Receptor Tyrosine Kinases)
Glioblastoma multiforme is the most frequent, aggressive and fatal type of brain tumor. Glioblastomas are characterized by their infiltrating nature, high proliferation rate and resistance to chemotherapy and radiation. Recently, oncologic therapy experienced a rapid evolution towards “targeted therapy,” which is the employment of drugs directed against particular targets that play essential roles in proliferation, survival and invasiveness of cancer cells. A number of molecules involved in signal transduction pathways are used as molecular targets for the treatment of various tumors. In fact, inhibitors of these molecules have already entered the clinic or are undergoing clinical trials. Cellular receptors are clear examples of such targets and in the case of glioblastoma multiforme, some of these receptors and their ligands have become relevant. In this review, the importance of glioblastoma multiforme in signaling pathways initiated by extracellular tyrosine kinase receptors such as EGFR, PDGFR and IGF-1R will be discussed. We will describe their ligands, family members, structure, activation mechanism, downstream molecules, as well as the interaction among these pathways. Lastly, we will provide an up-to-date review of the current targeted therapies in cancer, in particular glioblastoma that employ inhibitors of these pathways and their benefits. View Full-Text
Keywords: RTK; EGFR; PDGFR; IGF-1R; glioblastoma multiforme RTK; EGFR; PDGFR; IGF-1R; glioblastoma multiforme
Show Figures

Figure 1

MDPI and ACS Style

Carrasco-García, E.; Saceda, M.; Martínez-Lacaci, I. Role of Receptor Tyrosine Kinases and Their Ligands in Glioblastoma. Cells 2014, 3, 199-235.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop