Next Article in Journal
Acknowledgement to Reviewers of Cells in 2013
Next Article in Special Issue
Role of Receptor Tyrosine Kinases and Their Ligands in Glioblastoma
Previous Article in Journal
Loss of TRPV2 Homeostatic Control of Cell Proliferation Drives Tumor Progression
Previous Article in Special Issue
Unlocking Doors without Keys: Activation of Src by Truncated C-terminal Intracellular Receptor Tyrosine Kinases Lacking Tyrosine Kinase Activity
Article Menu

Export Article

Open AccessReview
Cells 2014, 3(1), 129-149;

Flotillins in Receptor Tyrosine Kinase Signaling and Cancer

Institute of Biochemistry, Medical faculty, University of Giessen, Friedrichstrasse 24, 35392 Giessen, Germany
Present address: Department of Molecular Haematology, Goethe University Medical School, 60590 Frankfurt, Germany.
Author to whom correspondence should be addressed.
Received: 11 December 2013 / Revised: 11 February 2014 / Accepted: 12 February 2014 / Published: 19 February 2014
(This article belongs to the Special Issue Receptor Tyrosine Kinases)
Full-Text   |   PDF [502 KB, uploaded 19 February 2014]   |  


Flotillins are highly conserved proteins that localize into specific cholesterol rich microdomains in cellular membranes. They have been shown to be associated with, for example, various signaling pathways, cell adhesion, membrane trafficking and axonal growth. Recent findings have revealed that flotillins are frequently overexpressed in various types of human cancers. We here review the suggested functions of flotillins during receptor tyrosine kinase signaling and in cancer. Although flotillins have been implicated as putative cancer therapy targets, we here show that great caution is required since flotillin ablation may result in effects that increase instead of decrease the activity of specific signaling pathways. On the other hand, as flotillin overexpression appears to be related with metastasis formation in certain cancers, we also discuss the implications of these findings for future therapy aspects. View Full-Text
Keywords: cancer; receptor tyrosine kinases; flotillins; metastasis; mitogen activated proteins kinase; insulin; diabetes cancer; receptor tyrosine kinases; flotillins; metastasis; mitogen activated proteins kinase; insulin; diabetes

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Banning, A.; Kurrle, N.; Meister, M.; Tikkanen, R. Flotillins in Receptor Tyrosine Kinase Signaling and Cancer. Cells 2014, 3, 129-149.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top