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Correction to Cells 2025, 14(4), 248.
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Correction

Correction: Alobaidi et al. Combinational Inhibition of MEK and AKT Synergistically Induces Melanoma Stem Cell Apoptosis and Blocks NRAS Tumor Growth. Cells 2025, 14, 248

by
Ryyan Alobaidi
1,2,†,
Nusrat Islam
1,†,
Toni Olkey
1,
Yogameenakshi Haribabu
1,
Mathew Shamo
1,
Peter Sykora
3,
Cynthia M. Simbulan-Rosenthal
1 and
Dean S. Rosenthal
1,*
1
Department of Biochemistry and Molecular & Cellular Biology, Georgetown University School of Medicine, Washington, DC 20057, USA
2
Department of Pathology, King Saud University College of Medicine, Riyadh 11461, Saudi Arabia
3
Amelia Technologies, LLC, Washington, DC 20001, USA
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Cells 2026, 15(8), 704; https://doi.org/10.3390/cells15080704
Submission received: 18 March 2026 / Accepted: 19 March 2026 / Published: 16 April 2026
Browse Figures
Versions Notes

Error in Figure

In the original publication [1], there were two mistakes in Figure 2C as published. After the dot plot data used in Figures 2C and 5B were re-examined, the dot plot results used in Figure 5B for trametinib (T) and trametinib+capivasertib (T+C)-treated+Dox BAKP cells were determined to have been inadvertently duplicated and used for the Figure 2C dot plot for T and T+C-treated-Dox BAKP cells. Figure 5B is correct; however, the duplicated dot plot data in Figure 2C need to be replaced with the correct dot plot data for T and T+C-treated-Dox BAKP cells. The corrected Figure 2 appears below.
The authors state that the scientific conclusions of this paper are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.

Reference

  1. Alobaidi, R.; Islam, N.; Olkey, T.; Haribabu, Y.; Shamo, M.; Sykora, P.; Simbulan-Rosenthal, C.M.; Rosenthal, D.S. Combinational Inhibition of MEK and AKT Synergistically Induces Melanoma Stem Cell Apoptosis and Blocks NRAS Tumor Growth. Cells 2025, 14, 248. [Google Scholar] [CrossRef] [PubMed]
Cells 15 00704 g002aCells 15 00704 g002b
Figure 2. Capivasertib enhances apoptosis in trametinib-treated BAKP (A) and POT (B) melanoma cell lines. Cells were seeded in equal numbers in 6-well plates in triplicate and then treated with trametinib and/or capivasertib. After 48 h of treatment, cells were subjected to Annexin-APC/Sytox Blue apoptosis assays. The percentage of total apoptosis (the sum of early and late apoptosis in the lower-right and upper-right quadrants of the dot plots, respectively) were quantified via flow cytometric analysis. Results are means ± SEM of three replicates of a representative experiment; results that were essentially the same were obtained in three independent experiments. p < 0.05 was considered significant; *, **, and **** represent p < 0.05, p < 0.01, and p < 0.0001, respectively. (C) Dot plot data used to generate the bar graphs in (A,B). (D) Representative phase contrast (left panel) and fluorescence (right panel) images of BAKP cells showing loss of mitochondrial membrane potential in BAKP cells treated with trametinib alone or in combination with capivasertib, but not in control cells or those incubated with capivasertib alone, indicating that apoptosis occurs through a mitochondrially mediated pathway. White-bordered squares show enlargement of select cells.
Figure 2. Capivasertib enhances apoptosis in trametinib-treated BAKP (A) and POT (B) melanoma cell lines. Cells were seeded in equal numbers in 6-well plates in triplicate and then treated with trametinib and/or capivasertib. After 48 h of treatment, cells were subjected to Annexin-APC/Sytox Blue apoptosis assays. The percentage of total apoptosis (the sum of early and late apoptosis in the lower-right and upper-right quadrants of the dot plots, respectively) were quantified via flow cytometric analysis. Results are means ± SEM of three replicates of a representative experiment; results that were essentially the same were obtained in three independent experiments. p < 0.05 was considered significant; *, **, and **** represent p < 0.05, p < 0.01, and p < 0.0001, respectively. (C) Dot plot data used to generate the bar graphs in (A,B). (D) Representative phase contrast (left panel) and fluorescence (right panel) images of BAKP cells showing loss of mitochondrial membrane potential in BAKP cells treated with trametinib alone or in combination with capivasertib, but not in control cells or those incubated with capivasertib alone, indicating that apoptosis occurs through a mitochondrially mediated pathway. White-bordered squares show enlargement of select cells.
Cells 15 00704 g002aCells 15 00704 g002b
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MDPI and ACS Style

Alobaidi, R.; Islam, N.; Olkey, T.; Haribabu, Y.; Shamo, M.; Sykora, P.; Simbulan-Rosenthal, C.M.; Rosenthal, D.S. Correction: Alobaidi et al. Combinational Inhibition of MEK and AKT Synergistically Induces Melanoma Stem Cell Apoptosis and Blocks NRAS Tumor Growth. Cells 2025, 14, 248. Cells 2026, 15, 704. https://doi.org/10.3390/cells15080704

AMA Style

Alobaidi R, Islam N, Olkey T, Haribabu Y, Shamo M, Sykora P, Simbulan-Rosenthal CM, Rosenthal DS. Correction: Alobaidi et al. Combinational Inhibition of MEK and AKT Synergistically Induces Melanoma Stem Cell Apoptosis and Blocks NRAS Tumor Growth. Cells 2025, 14, 248. Cells. 2026; 15(8):704. https://doi.org/10.3390/cells15080704

Chicago/Turabian Style

Alobaidi, Ryyan, Nusrat Islam, Toni Olkey, Yogameenakshi Haribabu, Mathew Shamo, Peter Sykora, Cynthia M. Simbulan-Rosenthal, and Dean S. Rosenthal. 2026. "Correction: Alobaidi et al. Combinational Inhibition of MEK and AKT Synergistically Induces Melanoma Stem Cell Apoptosis and Blocks NRAS Tumor Growth. Cells 2025, 14, 248" Cells 15, no. 8: 704. https://doi.org/10.3390/cells15080704

APA Style

Alobaidi, R., Islam, N., Olkey, T., Haribabu, Y., Shamo, M., Sykora, P., Simbulan-Rosenthal, C. M., & Rosenthal, D. S. (2026). Correction: Alobaidi et al. Combinational Inhibition of MEK and AKT Synergistically Induces Melanoma Stem Cell Apoptosis and Blocks NRAS Tumor Growth. Cells 2025, 14, 248. Cells, 15(8), 704. https://doi.org/10.3390/cells15080704

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