Partial Reprogramming Is Conserved from Insect to Mammal

Nicholas S. Tolwinski, PhD, is an Associate Professor in the Cancer and Stem Cell Biology Program at Duke-NUS Medical School. He received his B.A. from the University of Colorado in Boulder, majoring in Molecular, Cellular, and Developmental Biology, He received a PhD from Princeton University in Molecular Biology in 2004, He moved to Yale-NUS College as a founding member of the faculty in 2012 and joined Duke-NUS Medical School in 2022. He is interested in Signal transduction in embryonic development, Adult models for analysis of aging, and age-related disease.

Sheng Fong, MD PhD, is a consultant geriatrician-scientist at Ng Teng Fong General Hospital and an adjunct assistant professor at the National University of Singapore. He maintains an active clinical practice caring for frail older adults with complex age-related conditions. Patients remain central to his work, and his clinical practice continually informs his research, which focuses on improving care through earlier detection, accurate prognostication, and personalized interventions. To address current gaps in identifying latent disease and physiological decline, he has developed expertise in data science and machine learning, building clinical classifiers and risk models, most notably the biological aging clocks LinAge and LinAge2, to assess physiological resilience across the life course. He currently leads the validation of the LinAge2 clinical aging clock and its derivatives across multiple Singapore cohorts, including SG70, RESET, and CogAge, to ensure broad population applicability. In addition, he co-leads the Singapore Chinese Health Study and its SG70 and Beyond SG70@HOME sub-studies.

Jan Gruber, PhD, an Assistant Professor at the Division of Science, Yale-NUS College, a collaboration between Yale University and the National University of Singapore, and an Assistant Professor in the Department of Biochemistry, NUS. From 1995 to 1998, Jan Gruber studied physics at the RWTH-Aachen University in Germany before earning Part III of the Mathematical Tripos (MASt) at the University of Cambridge in the UK. From 1999 to 2004, he was a graduate student in the Laboratory of Molecular Biophysics, Department of Biochemistry at Oxford University. He earned his Master’s degree of Science in Biochemistry and Molecular Biophysics in 2000. His research focus on Ageing, Age-dependent dieseases, Interventions agains, Basic/Molecular Mechanisms of Ageing, Role of Mitochondria and Free Radicals in Ageing and Age-dependent Diseases and so on.