Next Article in Journal
Emerging Function of Prolactin-Inducible Protein—Is This Important Tear Protein Found in Alzheimer’s Disease?
Previous Article in Journal
Whole-Brain Connectome Identifies PMvLepRb Neurons as a Hypothalamic Hub Linking Metabolic State to Instinctive Behavior
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cells
Volume 15
Issue 11
10.3390/cells15111028
cells-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

SIRT7 Inhibits Adipose Tissue Browning Through Deacetylation of PPARγ2 at K382

by
Avizit Das
1,
Tatsuya Yoshizawa
1,2,*,
Daisuke Yamada
2,
Tomonori Tsuyama
3,
Yoshifumi Sato
1,
Tomoya Mizumoto
1,
Takeshi Yoneshiro
4,5,
Shingo Kajimura
6 and
Kazuya Yamagata
1,3,*
1
Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan
2
Cell Biology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 606-0823, Japan
3
Center for Metabolic Regulation of Healthy Aging, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan
4
Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan
5
Division of Metabolic Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo 153-8904, Japan
6
Beth Israel Deaconess Medical Center, Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA 02215, USA
*
Authors to whom correspondence should be addressed.
Cells 2026, 15(11), 1028; https://doi.org/10.3390/cells15111028
Submission received: 25 April 2026 / Revised: 28 May 2026 / Accepted: 2 June 2026 / Published: 3 June 2026
(This article belongs to the Section Cellular Metabolism)
Versions Notes

Abstract

Adipose tissue (AT) browning is an inducible cellular phenomenon that promotes lipid oxidation to increase energy expenditure, reducing adiposity. Various transcription regulators involved in the AT browning process have been reported, but their complex molecular mechanisms remain poorly understood. Here, we explore the effects of SIRT7, one of seven mammalian sirtuins, on AT browning and elucidate the underlying mechanisms. SIRT7 deficiency increased the expression of browning genes in beige adipocytes differentiated from subcutaneous white AT (scWAT) stromal vascular fraction (SVF) cells isolated from adipocyte-specific Sirt7 knockout (Sirt7 AdKO) mice. The effect of SIRT7 on beige adipocyte differentiation was confirmed in Sirt7 knockdown (KD) mouse scWAT and human supraclavicular brown AT (scBAT) SVF cell lines. Mechanistically, SIRT7 deacetylated PPARγ2 (peroxisome proliferator-activated receptor γ2) at lysine (K) 382, thereby attenuating interaction with the transcriptional coactivator PRDM16 (PR domain-containing 16). In differentiated beige adipocytes, the acetylation-mimicking mutant PPARγ2K382Q had higher transcriptional activity compared with the deacetylation-mimicking mutant PPARγ2K382R. Furthermore, the interaction between endogenous SIRT7 and PPARγ2 decreased at the onset of beige adipocyte differentiation. Our findings reveal that SIRT7 is an important thermogenic regulator that puts the brake on AT browning by deacetylating PPARγ2.
Keywords: browning; beige adipocytes; SIRT7; PPARγ; deacetylation; PRDM16 browning; beige adipocytes; SIRT7; PPARγ; deacetylation; PRDM16

Share and Cite

MDPI and ACS Style

Das, A.; Yoshizawa, T.; Yamada, D.; Tsuyama, T.; Sato, Y.; Mizumoto, T.; Yoneshiro, T.; Kajimura, S.; Yamagata, K. SIRT7 Inhibits Adipose Tissue Browning Through Deacetylation of PPARγ2 at K382. Cells 2026, 15, 1028. https://doi.org/10.3390/cells15111028

AMA Style

Das A, Yoshizawa T, Yamada D, Tsuyama T, Sato Y, Mizumoto T, Yoneshiro T, Kajimura S, Yamagata K. SIRT7 Inhibits Adipose Tissue Browning Through Deacetylation of PPARγ2 at K382. Cells. 2026; 15(11):1028. https://doi.org/10.3390/cells15111028

Chicago/Turabian Style

Das, Avizit, Tatsuya Yoshizawa, Daisuke Yamada, Tomonori Tsuyama, Yoshifumi Sato, Tomoya Mizumoto, Takeshi Yoneshiro, Shingo Kajimura, and Kazuya Yamagata. 2026. "SIRT7 Inhibits Adipose Tissue Browning Through Deacetylation of PPARγ2 at K382" Cells 15, no. 11: 1028. https://doi.org/10.3390/cells15111028

APA Style

Das, A., Yoshizawa, T., Yamada, D., Tsuyama, T., Sato, Y., Mizumoto, T., Yoneshiro, T., Kajimura, S., & Yamagata, K. (2026). SIRT7 Inhibits Adipose Tissue Browning Through Deacetylation of PPARγ2 at K382. Cells, 15(11), 1028. https://doi.org/10.3390/cells15111028

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Article metric data becomes available approximately 24 hours after publication online.
Back to TopTop