Next Article in Journal
Transcriptomic Profiling of iPS Cell-Derived Hepatocyte-like Cells Reveals Their Close Similarity to Primary Liver Hepatocytes
Previous Article in Journal
Inter-Relationship Between Melanoma Vemurafenib Tolerance Thresholds and Metabolic Pathway Choice
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cells
Volume 14
Issue 12
10.3390/cells14120924
cells-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Concurrent Physical Activity Protects Against C26 Adenocarcinoma Tumor-Mediated Cardiac and Skeletal Muscle Dysfunction and Wasting in Males

by
Louisa Tichy
1,
Kimberly F. Allred
2,
Erika T. Rezeli
3,
Michael F. Coleman
3,
Clinton D. Allred
2,
Stephen D. Hursting
3 and
Traci L. Parry
1,*
1
Department of Kinesiology, University of North Carolina at Greensboro, Greensboro, NC 27412, USA
2
Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC 27412, USA
3
Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
*
Author to whom correspondence should be addressed.
Cells 2025, 14(12), 924; https://doi.org/10.3390/cells14120924
Submission received: 21 April 2025 / Revised: 5 June 2025 / Accepted: 16 June 2025 / Published: 18 June 2025
(This article belongs to the Special Issue Emerging Topics in Cachexia)
Versions Notes

Abstract

Muscle loss unresponsive to nutritional supplementation affects up to 80% of cancer patients and severely reduces survival and treatment response. Exercise may help preserve muscle mass and function, yet the translatability of preclinical methods remains questionable. This study aimed to assess how voluntary wheel running, a clinically relevant physical activity, protects skeletal and cardiac muscle against cancer-mediated dysfunction and identify underlying molecular mechanisms. Methods: BALB/c mice were assigned to sedentary nontumor-bearing (SED+NT), sedentary tumor-bearing (SED+T), wheel run nontumor-bearing (WR+NT), and wheel run tumor-bearing (WR+T). Tumor-bearing groups received 5 × 105 C26 cells; WR mice had wheel access for 4 weeks. Muscle function and tissue were analyzed for protective mechanisms. Results: SED+T mice exhibited significant fat and lean mass loss, indicating cachexia, which was prevented in WR+T mice. SED+T also showed 15% reduced grip strength and cardiac dysfunction, while WR+T preserved function. WR+T mice had lower expression of muscle wasting markers (Atrogin1, MuRF1, GDF15, GDF8/11). Physical activity also reduced tumor mass by 57% and volume by 37%. Conclusion: Voluntary wheel running confers tumor-suppressive, myoprotective, and cardioprotective effects. These findings support physical activity as a non-pharmacological strategy to combat cancer-related muscle wasting and dysfunction.
Keywords: cancer; muscle wasting; exercise; physical activity; protection cancer; muscle wasting; exercise; physical activity; protection

Share and Cite

MDPI and ACS Style

Tichy, L.; Allred, K.F.; Rezeli, E.T.; Coleman, M.F.; Allred, C.D.; Hursting, S.D.; Parry, T.L. Concurrent Physical Activity Protects Against C26 Adenocarcinoma Tumor-Mediated Cardiac and Skeletal Muscle Dysfunction and Wasting in Males. Cells 2025, 14, 924. https://doi.org/10.3390/cells14120924

AMA Style

Tichy L, Allred KF, Rezeli ET, Coleman MF, Allred CD, Hursting SD, Parry TL. Concurrent Physical Activity Protects Against C26 Adenocarcinoma Tumor-Mediated Cardiac and Skeletal Muscle Dysfunction and Wasting in Males. Cells. 2025; 14(12):924. https://doi.org/10.3390/cells14120924

Chicago/Turabian Style

Tichy, Louisa, Kimberly F. Allred, Erika T. Rezeli, Michael F. Coleman, Clinton D. Allred, Stephen D. Hursting, and Traci L. Parry. 2025. "Concurrent Physical Activity Protects Against C26 Adenocarcinoma Tumor-Mediated Cardiac and Skeletal Muscle Dysfunction and Wasting in Males" Cells 14, no. 12: 924. https://doi.org/10.3390/cells14120924

APA Style

Tichy, L., Allred, K. F., Rezeli, E. T., Coleman, M. F., Allred, C. D., Hursting, S. D., & Parry, T. L. (2025). Concurrent Physical Activity Protects Against C26 Adenocarcinoma Tumor-Mediated Cardiac and Skeletal Muscle Dysfunction and Wasting in Males. Cells, 14(12), 924. https://doi.org/10.3390/cells14120924

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop