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Article

Excess Weight Impairs Oocyte Quality, as Reflected by mtDNA and BMP-15

by
Emiliya Sigal
1,2,*,
Maya Shavit
1,2,
Yuval Atzmon
1,2,
Nardin Aslih
1,2,
Asaf Bilgory
1,2,
Daniella Estrada
1,
Mediea Michaeli
1,
Nechama Rotfarb
1,
Yasmin Shibli Abu-Raya
1,2,
Shilhav Meisel-Sharon
1 and
Einat Shalom-Paz
1,2
1
IVF Unit, Department of Obstetrics and Gynecology, Hillel-Yaffe Medical Center, Hadera 3820302, Israel
2
A Ruth and Bruce Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa 3525433, Israel
*
Author to whom correspondence should be addressed.
Cells 2024, 13(22), 1872; https://doi.org/10.3390/cells13221872
Submission received: 14 September 2024 / Revised: 27 October 2024 / Accepted: 5 November 2024 / Published: 12 November 2024
(This article belongs to the Special Issue Cellular and Molecular Mechanisms in Reproductive System Diseases)
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Abstract

This prospective, case-control study evaluated the impact of obesity on oocyte quality based on mtDNA expression in cumulus cells (CC), and on bone morphogenetic protein 15 (BMP-15) and heparan sulfate proteoglycan 2 (HSPG2) in follicular fluid (FF). It included women 18 to <40 years of age, divided according to BMI < 24.9 (Group 1, n = 28) and BMI > 25 (Group 2, n = 22). Demographics, treatment, and pregnancy outcomes were compared. The mtDNA in CC, BMP-15, HSPG2, the lipid profile, the hormonal profile, and C-reactive protein were evaluated in FF and in blood samples. The BMP-15 levels in FF and the mitochondrial DNA in CC were higher in Group 1 (38.8 ± 32.5 vs. 14.3 ± 10.8 ng/mL; p = 0.001 and 1.10 ± 0.3 vs. 0.87 ± 0.18-fold change; p = 0.016, respectively) than in Group 2. High-density lipoprotein levels in blood and FF were higher in Group 1 (62 ± 18 vs. 50 ± 12 mg/dL; p = 0.015 and 34 ± 26 vs. 20.9 ± 7.2 mg/dL; p = 0.05, respectively). Group 2 had higher blood C-reactive protein (7.1 ± 5.4 vs. 3.4 ± 4.3 mg/L; p = 0.015), FF (5.2 ± 3.8 vs. 1.5 ± 1.6 mg/L; p = 0.002) and low-density lipoprotein levels (91 ± 27 vs. 71 ± 22 mg/dL; p = 0.008) vs. Group 1. Group 1 demonstrated a trend toward a better clinical pregnancy rate (47.8% vs. 28.6%: p = 0.31) and frozen embryo transfer rate (69.2% vs. 53.8; p = 0.69). Higher BMI resulted in lower BMP-15 levels and reduced mtDNA expression, which reflect decreased oocyte quality in overweight women.
Keywords: obesity; body mass index; BMI; overweight; oocyte quality; BMP-15; HSPG2; mtDNA obesity; body mass index; BMI; overweight; oocyte quality; BMP-15; HSPG2; mtDNA

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MDPI and ACS Style

Sigal, E.; Shavit, M.; Atzmon, Y.; Aslih, N.; Bilgory, A.; Estrada, D.; Michaeli, M.; Rotfarb, N.; Shibli Abu-Raya, Y.; Meisel-Sharon, S.; et al. Excess Weight Impairs Oocyte Quality, as Reflected by mtDNA and BMP-15. Cells 2024, 13, 1872. https://doi.org/10.3390/cells13221872

AMA Style

Sigal E, Shavit M, Atzmon Y, Aslih N, Bilgory A, Estrada D, Michaeli M, Rotfarb N, Shibli Abu-Raya Y, Meisel-Sharon S, et al. Excess Weight Impairs Oocyte Quality, as Reflected by mtDNA and BMP-15. Cells. 2024; 13(22):1872. https://doi.org/10.3390/cells13221872

Chicago/Turabian Style

Sigal, Emiliya, Maya Shavit, Yuval Atzmon, Nardin Aslih, Asaf Bilgory, Daniella Estrada, Mediea Michaeli, Nechama Rotfarb, Yasmin Shibli Abu-Raya, Shilhav Meisel-Sharon, and et al. 2024. "Excess Weight Impairs Oocyte Quality, as Reflected by mtDNA and BMP-15" Cells 13, no. 22: 1872. https://doi.org/10.3390/cells13221872

APA Style

Sigal, E., Shavit, M., Atzmon, Y., Aslih, N., Bilgory, A., Estrada, D., Michaeli, M., Rotfarb, N., Shibli Abu-Raya, Y., Meisel-Sharon, S., & Shalom-Paz, E. (2024). Excess Weight Impairs Oocyte Quality, as Reflected by mtDNA and BMP-15. Cells, 13(22), 1872. https://doi.org/10.3390/cells13221872

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