Potential Transcript-Based Biomarkers Predicting Clinical Outcomes of HPV-Positive Head and Neck Squamous Cell Carcinoma Patients
Abstract
:1. Introduction
2. Human Papillomavirus as a Determining Factor in the Establishment of HNSCC
3. Proposed Transcript-Based Prognostic Biomarkers for HPV-Positive HNSCC
3.1. lncRNAs
3.2. mRNAs
3.3. miRNAs
4. Future Directions and Perspectives
4.1. Heterogeneity of HPV-Associated Biology as a Source of New Clinical Biomarkers
4.2. Unraveling Tumor Biology by HPV-Associated Circulating miRNAs
5. Concluding Remarks
Author Contributions
Funding
Conflicts of Interest
References
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Name | Level | Biomolecule | Cancer Type | Clinical Outcome Impact | References |
---|---|---|---|---|---|
PRINS (Expression) | High | lncRNA | HNSCC | Improved OS and DFS | [43] |
CD3E, IRF4, ZAP70 (UWO3 Risk score) | Low | mRNA | OPSCC | Improved OS and DFS | [44] |
Clorf105, CGA, CHRNA2, CRIP3, CTAG2, ENPP6, NEFH, RNF212 (Risk score) | High | mRNA | HNSCC | Worse OS and DFS | [45] |
S100A9 THBS4 (Expression) | Low High | mRNA | OPSCC | Worse MFS | [46] |
NRF2 NQO1 TP53 KEAP1 (Expression) | Low Low Low High | mRNA | HNSCC | Improved OS | [47] |
mCBX5, mCDKN2A, mMCM5, mMCM6, mRBBP7, mTMPO, mVCAM1 (Risk score) | High | mRNA | HNSCC | Worse OS | [48] |
ZNF540 (Expression) | High | mRNA | HNSCC | Improved OS | [49] |
FDCSP NEFH FAM3B (Expression) | High High High | mRNA | HNSCC | Improved OS | [50] |
FDCSP (Expression) CD8+ T cells (Infiltration) | High High | mRNA | HNSCC | Improved OS | [50] |
U62317.3 hsa-miR-375 KLHD (Expression) | High Low High | lncRNA miRNA mRNA | HNSCC | Improved OS | [51] |
PDLIM5 USP25 SLMAP (Expression) | Low Low Low | mRNA | HNSCC | Worse OS | [51] |
SLC25A39 GJB2 (Expression) | High High | mRNA | HNSCC | Worse OS | [52] |
DOCK8 (Expression) | High | mRNA | HNSCC | Improved OS and DFS | [53] |
RASSF8, LGALSL, TRIB3, FAM106A, MICAL3, STIP1, ZNF146, ZNF284, TPST1, PSMG3, CPEB2, SH3D21, CNOT2, ENTPD6, PPIAL4C, SARS, SULT1E1, EAF1, LOC100128108, PLPPR2, OTUD4, MUL1, BCL2L13, GUCY1B1, MRPL45, GALK1, RSU1, AVPI1, PDPR, ALKBH6, HCK, ATP6V1A, TAF5L, BUD13, TNFRSF6B, ACOT11, RNF167, ORAI1, CRYBG3, HDDC3, CREB3L4, TMEM246, PEX16, HAUS1, NUP214, AURKB, OGN, FBXO41, SLFN13, CXCL13, COMMD3, FOXRED2, FPGS, UCP2, GLUL, LYN, MEI1, CYBA, NUP210, ARHGAP4 (Risk score) | Low | mRNA | OPSCC | Improved OS, RFS and MFS | [54] |
SDHC COX7A1 COX16 COX17 ELOVL6 GOT2 SLC16A2 (Expression) | Low Low Low Low Low Low Low | mRNA | HNSCC | Improved OS | [55] |
AATF, APP, GNPDA1, HPRT1, LASP1, P4HA1, ILF3 (Risk score) | High | mRNA | HNSCC | Worse OS | [56] |
hsa-miR-380-5p, hsa-miR-493-3p, hsa-miR-454-5p, hsa-miR-376c-3p, hsa-miR-338-5p, hsa-miR-16-1-3p, hsa-miR-378a-3p (Risk score) | Low | miRNA | HNSCC | Improved OS | [57] |
miR-155 (Expression) | High | miRNA | TSCC/BOTSCC | Improved OS and PFS | [58] |
hsa-miR-27a-3p, hsa-miR-455-5p, hsa-miR-203a-3p, hsa-miR-584-5p, hsa-miR-24-3p, hsa-miR-548k, hsa-miR-126-3p, hsa-miR-126-5p, hsa-miR-365a-5p, hsa-miR-98-5p, hsa-miR-151b, hsa-miR-361-3p, hsa-miR-374c-5p, hsa-miR-150-5p, hsa-miR-374b-5p, hsa-miR-107, hsa-miR-125b-5p, hsa-miR-1287-5p, hsa-miR-146a-5p, hsa-miR-106a-5p, hsa-miR-15b-5p, hsa-miR-20b-5p, hsa-miR-532-3p, hsa-miR-361-5p, hsa-miR-363-3p, hsa-miR-625-3p (Risk score) | High | miRNA | OPSCC | Worse OS, RFS and MFS | [59] |
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Muñoz-Bello, J.O.; Romero-Córdoba, S.L.; García-Chávez, J.N.; González-Espinosa, C.; Langley, E.; Lizano, M. Potential Transcript-Based Biomarkers Predicting Clinical Outcomes of HPV-Positive Head and Neck Squamous Cell Carcinoma Patients. Cells 2024, 13, 1107. https://doi.org/10.3390/cells13131107
Muñoz-Bello JO, Romero-Córdoba SL, García-Chávez JN, González-Espinosa C, Langley E, Lizano M. Potential Transcript-Based Biomarkers Predicting Clinical Outcomes of HPV-Positive Head and Neck Squamous Cell Carcinoma Patients. Cells. 2024; 13(13):1107. https://doi.org/10.3390/cells13131107
Chicago/Turabian StyleMuñoz-Bello, J. Omar, Sandra L. Romero-Córdoba, J. Noé García-Chávez, Claudia González-Espinosa, Elizabeth Langley, and Marcela Lizano. 2024. "Potential Transcript-Based Biomarkers Predicting Clinical Outcomes of HPV-Positive Head and Neck Squamous Cell Carcinoma Patients" Cells 13, no. 13: 1107. https://doi.org/10.3390/cells13131107
APA StyleMuñoz-Bello, J. O., Romero-Córdoba, S. L., García-Chávez, J. N., González-Espinosa, C., Langley, E., & Lizano, M. (2024). Potential Transcript-Based Biomarkers Predicting Clinical Outcomes of HPV-Positive Head and Neck Squamous Cell Carcinoma Patients. Cells, 13(13), 1107. https://doi.org/10.3390/cells13131107