Role of Autophagy in Ehrlichia-Induced Liver Injury
Author Contributions
Conflicts of Interest
References
- Levine, B.; Klionsky, D.J. Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev. Cell. 2004, 6, 463–477. [Google Scholar] [CrossRef]
- Melia, T.J.; Lystad, A.H.; Simonsen, A. Autophagosome biogenesis: From membrane growth to closure. J. Cell. Biol. 2020, 219. [Google Scholar] [CrossRef] [PubMed]
- Ravanan, P.; Srikumar, I.F.; Talwar, P. Autophagy: The spotlight for cellular stress responses. Life Sci. 2017, 188, 53–67. [Google Scholar] [CrossRef] [PubMed]
- Otomo, C.; Metlagel, Z.; Takaesu, G.; Otomo, T. Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy. Nat. Struct. Mol. Biol. 2013, 20, 59–66. [Google Scholar] [CrossRef] [PubMed]
- McEwan, D.G.; Popovic, D.; Gubas, A.; Terawaki, S.; Suzuki, H.; Stadel, D.; Coxon, F.P.; Miranda de Stegmann, D.; Bhogaraju, S.; Maddi, K.; et al. PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins. Mol. Cell. 2015, 57, 39–54. [Google Scholar] [CrossRef]
- Itakura, E.; Kishi-Itakura, C.; Mizushima, N. The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell 2012, 151, 1256–1269. [Google Scholar] [CrossRef]
- Levine, B.; Kroemer, G. Autophagy in the pathogenesis of disease. Cell 2008, 132, 27–42. [Google Scholar] [CrossRef]
- Ismail, N.; Sharma, A.; Soong, L.; Walker, D.H. Review: Protective Immunity and Immunopathology of Ehrlichiosis. Zoonoses 2022, 2. [Google Scholar] [CrossRef]
- Kader, M.; El Andaloussi, A.; Vorhaour, J.; Tamama, K.; Nieto, N.; Scott, M.J.; Ismail, N. Interferon Type I Regulates Inflammasome Activation and High Mobility Group Box 1 Translocation in Hepatocytes During Ehrlichia-Induced Acute Liver Injury. Hepatol. Commun. 2021, 5, 33–51. [Google Scholar] [CrossRef]
- Abdelaziz, D.H.; Khalil, H.; Cormet-Boyaka, E.; Amer, A.O. The cooperation between the autophagy machinery and the inflammasome to implement an appropriate innate immune response: Do they regulate each other? Immunol. Rev. 2015, 265, 194–204. [Google Scholar] [CrossRef]
- Rohde, K.H.; Abramovitch, R.B.; Russell, D.G. Mycobacterium tuberculosis invasion of macrophages: Linking bacterial gene expression to environmental cues. Cell Host Microbe 2007, 2, 352–364. [Google Scholar] [CrossRef]
- Gutierrez, M.G.; Master, S.S.; Singh, S.B.; Taylor, G.A.; Colombo, M.I.; Deretic, V. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 2004, 119, 753–766. [Google Scholar] [CrossRef] [PubMed]
- Watson, R.O.; Manzanillo, P.S.; Cox, J.S.; Extracellular, M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway. Cell 2012, 150, 803–815. [Google Scholar] [CrossRef]
- Sharma, A.K.; Dhasmana, N.; Dubey, N.; Kumar, N.; Gangwal, A.; Gupta, M.; Singh, Y. Bacterial Virulence Factors: Secreted for Survival. Indian J. Microbiol. 2017, 57, 1–10. [Google Scholar] [CrossRef]
- Chai, Q.; Zhang, Y.; Liu, C.H. Mycobacterium tuberculosis: An Adaptable Pathogen Associated With Multiple Human Diseases. Front. Cell. Infect. Microbiol. 2018, 8, 158. [Google Scholar] [CrossRef] [PubMed]
- Rikihisa, Y. Subversion of RAB5-regulated autophagy by the intracellular pathogen Ehrlichia chaffeensis. Small GTPases 2019, 10, 343–349. [Google Scholar] [CrossRef]
- Yuan, W.; Song, C. The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways. Biochem. Res. Int. 2020, 2020, 4186308. [Google Scholar] [CrossRef] [PubMed]
- Kader, M.; Alaoui-EL-Azher, M.; Vorhauer, J.; Kode, B.B.; Wells, J.Z.; Stolz, D.; Michalopoulos, G.; Wells, A.; Scott, M.; Ismail, N. MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock. PLoS Pathog. 2017, 13, e1006644. [Google Scholar] [CrossRef]
- Kim, J.; Kundu, M.; Viollet, B.; Guan, K.-L. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 2011, 13, 132–141. [Google Scholar] [CrossRef]
- Chen, J.; Guo, Q.; Chen, Q.; Chen, Y.; Chen, D.; Chen, Z.; Wang, X.; Huang, Y. Interleukin 10 inhibits oxidative stress-induced autophagosome formation in hepatic stellate cells by activating the mTOR-STAT3 pathway. Exp. Cell Res. 2022, 411, 113001. [Google Scholar] [CrossRef]
- Codogno, P.; Mehrpour, M.; Proikas-Cezanne, T. Canonical and non-canonical autophagy: Variations on a common theme of self-eating? Nat. Rev. Mol. Cell. Biol. 2011, 13, 7–12. [Google Scholar] [CrossRef] [PubMed]
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Sharma, A.K.; Ismail, N. Role of Autophagy in Ehrlichia-Induced Liver Injury. Cells 2023, 12, 1334. https://doi.org/10.3390/cells12091334
Sharma AK, Ismail N. Role of Autophagy in Ehrlichia-Induced Liver Injury. Cells. 2023; 12(9):1334. https://doi.org/10.3390/cells12091334
Chicago/Turabian StyleSharma, Aditya Kumar, and Nahed Ismail. 2023. "Role of Autophagy in Ehrlichia-Induced Liver Injury" Cells 12, no. 9: 1334. https://doi.org/10.3390/cells12091334