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Cells
Volume 12
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10.3390/cells12060940
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Review

Venom Peptides, Polyphenols and Alkaloids: Are They the Next Antidiabetics That Will Preserve β-Cell Mass and Function in Type 2 Diabetes?

by
Michele Lodato
1,
Valérie Plaisance
1,
Valérie Pawlowski
1,
Maxime Kwapich
1,2,
Alexandre Barras
1,
Emeline Buissart
1,
Stéphane Dalle
3,
Sabine Szunerits
1,
Jérôme Vicogne
4,
Rabah Boukherroub
1 and
Amar Abderrahmani
1,*
1
University Lille, CNRS, Centrale Lille, University Polytechnique Hauts-de-France, UMR 8520, IEMN, F-59000 Lille, France
2
Service de Diabétologie et d’Endocrinologie, CH Dunkerque, 59385 Dunkirk, France
3
Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, 34094 Montpellier, France
4
University Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, F-59000 Lille, France
*
Author to whom correspondence should be addressed.
Cells 2023, 12(6), 940; https://doi.org/10.3390/cells12060940
Submission received: 14 February 2023 / Revised: 9 March 2023 / Accepted: 17 March 2023 / Published: 20 March 2023
(This article belongs to the Special Issue Insulin Secretion Research Is More than Diabetes)
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Abstract

Improvement of insulin secretion by pancreatic β-cells and preservation of their mass are the current challenges that future antidiabetic drugs should meet for achieving efficient and long-term glycemic control in patients with type 2 diabetes (T2D). The successful development of glucagon-like peptide 1 (GLP-1) analogues, derived from the saliva of a lizard from the Helodermatidae family, has provided the proof of concept that antidiabetic drugs directly targeting pancreatic β-cells can emerge from venomous animals. The literature reporting on the antidiabetic effects of medicinal plants suggests that they contain some promising active substances such as polyphenols and alkaloids, which could be active as insulin secretagogues and β-cell protectors. In this review, we discuss the potential of several polyphenols, alkaloids and venom peptides from snake, frogs, scorpions and cone snails. These molecules could contribute to the development of new efficient antidiabetic medicines targeting β-cells, which would tackle the progression of the disease.
Keywords: diabetes; insulin secretagogues; pancreatic beta cell; venom; polyphenols; alkaloids; peptides diabetes; insulin secretagogues; pancreatic beta cell; venom; polyphenols; alkaloids; peptides

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MDPI and ACS Style

Lodato, M.; Plaisance, V.; Pawlowski, V.; Kwapich, M.; Barras, A.; Buissart, E.; Dalle, S.; Szunerits, S.; Vicogne, J.; Boukherroub, R.; et al. Venom Peptides, Polyphenols and Alkaloids: Are They the Next Antidiabetics That Will Preserve β-Cell Mass and Function in Type 2 Diabetes? Cells 2023, 12, 940. https://doi.org/10.3390/cells12060940

AMA Style

Lodato M, Plaisance V, Pawlowski V, Kwapich M, Barras A, Buissart E, Dalle S, Szunerits S, Vicogne J, Boukherroub R, et al. Venom Peptides, Polyphenols and Alkaloids: Are They the Next Antidiabetics That Will Preserve β-Cell Mass and Function in Type 2 Diabetes? Cells. 2023; 12(6):940. https://doi.org/10.3390/cells12060940

Chicago/Turabian Style

Lodato, Michele, Valérie Plaisance, Valérie Pawlowski, Maxime Kwapich, Alexandre Barras, Emeline Buissart, Stéphane Dalle, Sabine Szunerits, Jérôme Vicogne, Rabah Boukherroub, and et al. 2023. "Venom Peptides, Polyphenols and Alkaloids: Are They the Next Antidiabetics That Will Preserve β-Cell Mass and Function in Type 2 Diabetes?" Cells 12, no. 6: 940. https://doi.org/10.3390/cells12060940

APA Style

Lodato, M., Plaisance, V., Pawlowski, V., Kwapich, M., Barras, A., Buissart, E., Dalle, S., Szunerits, S., Vicogne, J., Boukherroub, R., & Abderrahmani, A. (2023). Venom Peptides, Polyphenols and Alkaloids: Are They the Next Antidiabetics That Will Preserve β-Cell Mass and Function in Type 2 Diabetes? Cells, 12(6), 940. https://doi.org/10.3390/cells12060940

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