The Research Progress in Transforming Growth Factor-β2

Round 1

Reviewer 1 Report

The authors contributed a well-organized and comprehensive review on the biological mechanisms of pathological relevances of TGF-b2 which is a important cytokine playing multi-faceted roles in biological development and function regulations. Although this review is quite informative and insightful, authors can do the following to further increase the impact of this article:

1. The authors mentioned the relations between TGF-b2 and pathogenesis of several diseases but only provided very limited information regarding how to use TGF-b2 as a potential therapeutic targets for treating these diseases.

2. Many of the citations were from before 2010 or even 2000. Could author update the references to include some more recently-published findings of TGF-b?

Author Response

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Author Response File: Author Response.pdf

Reviewer 2 Report

The authors Wang et al have compiled a comprehensive review of the recent advances in research of Transforming growth factor-beta 2 (TGF-β2). This manuscript is well structured and laid out and I have only two comments.

- in Table 2 please do not use contractions ("can't activate"), rather use a more appropriate term.

- You mention the activation of TGF beta proteins through high heat ranging from 65°C to 100°C. Protein activation is reached at 80°C which both puzzling, and intriguing. Does this also refer to biological activity and reactivity? Please elaborate a bit more on the biological relevance of this data, if there is information available. I assume it was only cell culture-derived data but is there more info about heat activation of TGF beta 2 protein e.g. in high fever (40°C)?

Author Response

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Reviewer 3 Report

The manuscript 'The research progress of transforming growth factor-B2" is a very interesting manuscript aimed to identified role TGfbeta2 in cellular biology and different biological processes.

Several comments:

The authors could reduce the length of manuscript if will remove unnecessary modifiers:  

1.    Follow the text a lot of: Authors et al found that…, Autor show or reportes….., These studies suggest….

2.     Missed References: lines: 35, 58-60, 62, 68, 200-202…continue to all text

3.    Line 37: Tgfb1-/- mice; not all mice died around 20 days, actually 60% die in uterus.

4.    Missed description of Fig 1A in the text

5.    Line 78-98: Text is hard to understand, not everything related to TGFbeta2. Figure could help.

6.    Part the activation of TGFbeta2: a lot of data not related to TGFbeta2.  

7.    Table 3 references 75,76 not correct. Refer 78, upregulation in endothelial cells does not mean cardiovascular diseases. Also, initialization of myocardial fibrosis is TGFbeta1.

8.    Cardiovascular system: mix human, mice, heart, cardiomyopathy, fibrosis, vascular system. Similar situation with musculoskeletal system.

9.    Immune system and inflammation are not the same. 8-9: Difficulties understand “Organ-system: sections due to the absence of construction of logical story.

NA

Author Response

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