The Role of Ferroptosis in Adverse Left Ventricular Remodeling Following Acute Myocardial Infarction
Abstract
:1. Introduction
2. Features and Mechanisms
2.1. Lipid Peroxidation and Iron Homeostasis
2.2. Disruption of Antioxidant Systems
2.2.1. GPX4-Dependent Antioxidant Mechanisms
2.2.2. GPX4-Independent Antioxidant Mechanisms
2.2.3. Mitochondria-Dependent Ferroptosis
3. Ferroptosis in I/R Injury and LV Remodeling
3.1. Ferroptosis in Cardiomyocyte Cell Death
3.1.1. Role of Iron in I/R Injury
3.1.2. Antioxidant System Disruption in I/R Injury
3.1.3. Lipid Peroxidation in Ischemia-Reperfusion
3.1.4. Identification of Ferroptosis in Cardiomyocytes
3.2. Ferroptosis and Inflammation during I/R Injury
3.2.1. Inflammation Following Ferroptosis
3.2.2. Ferroptosis and Inflammatory Cells
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
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Komai, K.; Kawasaki, N.K.; Higa, J.K.; Matsui, T. The Role of Ferroptosis in Adverse Left Ventricular Remodeling Following Acute Myocardial Infarction. Cells 2022, 11, 1399. https://doi.org/10.3390/cells11091399
Komai K, Kawasaki NK, Higa JK, Matsui T. The Role of Ferroptosis in Adverse Left Ventricular Remodeling Following Acute Myocardial Infarction. Cells. 2022; 11(9):1399. https://doi.org/10.3390/cells11091399
Chicago/Turabian StyleKomai, Kyoko, Nicholas K. Kawasaki, Jason K. Higa, and Takashi Matsui. 2022. "The Role of Ferroptosis in Adverse Left Ventricular Remodeling Following Acute Myocardial Infarction" Cells 11, no. 9: 1399. https://doi.org/10.3390/cells11091399