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Ribosomes and Ribosomal Proteins Promote Plasticity and Stemness Induction in Glioma Cells via Reprogramming

Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara 252-0374, Japan
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Academic Editors: Javier S. Castresana and Bárbara Meléndez
Cells 2022, 11(14), 2142; https://doi.org/10.3390/cells11142142
Received: 27 May 2022 / Revised: 1 July 2022 / Accepted: 5 July 2022 / Published: 7 July 2022
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Cancers: Glioblastoma II)
Glioblastoma multiforme (GBM) is a lethal tumor that develops in the adult brain. Despite advances in therapeutic strategies related to surgical resection and chemo-radiotherapy, the overall survival of patients with GBM remains unsatisfactory. Genetic research on mutation, amplification, and deletion in GBM cells is important for understanding the biological aggressiveness, diagnosis, and prognosis of GBM. However, the efficacy of drugs targeting the genetic abnormalities in GBM cells is limited. Investigating special microenvironments that induce chemo-radioresistance in GBM cells is critical to improving the survival and quality of life of patients with GBM. GBM cells acquire and maintain stem-cell-like characteristics via their intrinsic potential and extrinsic factors from their special microenvironments. The acquisition of stem-cell-like phenotypes and aggressiveness may be referred to as a reprogramming of GBM cells. In addition to protein synthesis, deregulation of ribosome biogenesis is linked to several diseases including cancer. Ribosomal proteins possess both tumor-promotive and -suppressive functions as extra-ribosomal functions. Incorporation of ribosomes and overexpression of ribosomal protein S6 reprogram and induce stem-cell-like phenotypes in GBM cells. Herein, we review recent literature and our published data on the acquisition of aggressiveness by GBM and discuss therapeutic options through reprogramming. View Full-Text
Keywords: ribosomal protein; reprogramming; glioblastoma; extra-ribosomal function; microenvironment; glioma stem cell; ribosomal protein S6; ribosome biogenesis; transdifferentiation; plasticity ribosomal protein; reprogramming; glioblastoma; extra-ribosomal function; microenvironment; glioma stem cell; ribosomal protein S6; ribosome biogenesis; transdifferentiation; plasticity
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MDPI and ACS Style

Hide, T.; Shibahara, I.; Inukai, M.; Shigeeda, R.; Kumabe, T. Ribosomes and Ribosomal Proteins Promote Plasticity and Stemness Induction in Glioma Cells via Reprogramming. Cells 2022, 11, 2142. https://doi.org/10.3390/cells11142142

AMA Style

Hide T, Shibahara I, Inukai M, Shigeeda R, Kumabe T. Ribosomes and Ribosomal Proteins Promote Plasticity and Stemness Induction in Glioma Cells via Reprogramming. Cells. 2022; 11(14):2142. https://doi.org/10.3390/cells11142142

Chicago/Turabian Style

Hide, Takuichiro, Ichiyo Shibahara, Madoka Inukai, Ryota Shigeeda, and Toshihiro Kumabe. 2022. "Ribosomes and Ribosomal Proteins Promote Plasticity and Stemness Induction in Glioma Cells via Reprogramming" Cells 11, no. 14: 2142. https://doi.org/10.3390/cells11142142

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