New Insights into Hippo/YAP Signaling in Fibrotic Diseases
Abstract
:1. Introduction
2. Hippo Signaling Pathway in Cardiac Fibrosis
3. Hippo Signaling Pathway in Pulmonary Fibrosis
4. Hippo Signaling Pathway in Liver Fibrosis
5. Hippo Signaling Pathway in Renal Fibrosis
6. Hippo Signaling Pathway in Skin Fibrosis
7. Hippo Signaling Pathway in Fibrosis of Other Organs
Name of the Compounds | Mode of Actin | Experimental Study |
---|---|---|
Verteporfin [13,15,17,18,94,95,97] | Interference of YAP/TAZ-TEAD complex | |
XMU-MP-1 [39] | MST1/2 blocker | TAC-induced cardiac fibrosis in mice. |
Qishen granules [43] | Disrupt YAP/TAZ expression | Reduce the fibrogenic protein expression in HF-hearts of the rat. |
SKI [27] | Inducing proteasomal degradation of TAZ through the interaction with LIMD1 | Inhibits the transition of primary rat cardiac fibroblast to myofibroblasts. |
Lovastatin [44] | Suppression of YAP/TAZ signaling | Alleviates the AngII-induced cardiac fibrosis in mice. |
Sulfur dioxide (SO2) [45] | Inhibits MST1/2 | Prevent the myocardial fibrosis in diabetic rats |
Melatonin [69] | interrupting the translocation of YAP into the nucleus |
|
Icariin [70] | Inhibition of YAP function | Prevents the bleomycin-induced PF in rats. |
Simvastatin [67] | Modulates YAP localization | Reduces established fibrosis in bleomycin-challenged mouse IPF. |
PP242 [16] | Inhibits mTORC2 and suppresses YAP/TAZ | Inhibits the fibroblasts activation in UUO nephropathy induced mouse kidney fibrosis |
FSLLRY-NH2 [104] | Selectively inhibits YAP activity | Blocks the endothelial-to-mesenchymal transition and reduces the UUO-induced kidney fibrosis. |
Kindlin-2 siRNA [108] | Induces the degradation of MOB1 and promotes the nuclear translocation of YAP | Attenuates UUO-induced renal fibrosis in mice. |
Exosomes [105] | Promotes the βTrCP-mediated ubiquitination and degradation of YAP | Attenuates UUO-induced renal fibrosis. |
Fluphenazine dihydrochloride, (a DRD2 antagonist) [100] | Suppress YAP activity and induce the type I interferon signaling | Reduces CCl4-induced liver fibrosis. |
LPA [97] | YAP activator | Prevent IR-induced liver fibrogenesis in mice. |
Dihydrexidine (a DRD1 agonist) [7] | Blocks YAP/TAZ | Reverse HSCs activation and bile duct ligation-induced hepatic fibrosis in mice |
Tricyclic antidepressants [14] | Inhibit acid ceramidase and YAP/TAZ activity | Reduces human HSCs-activation |
ω-3 PUFAs [98] | Promoting YAP/TAZ degradation in a proteasome-dependent manner |
|
RhoA siRNA [9] | Reduces YAP/TAZ expression and augments the LATS1/2 activity | Halt the liver fibrosis |
Morin [99] | Reduces YAP/TAZ expression while activating the MST1 and LATS1 expression |
|
Dimethyl fumarate (DMF) [110] | Inhibition of YAP/TAZ |
|
Y27632 [115] | Inhibition of ROCK1 | Inhibits YAP/TAZ-dependent activation of fibrotic events in intestinal fibroblasts and DSS-induced chronic colitis mice. |
8. Conclusions and Remarks
Author Contributions
Funding
Conflicts of Interest
References
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Mia, M.M.; Singh, M.K. New Insights into Hippo/YAP Signaling in Fibrotic Diseases. Cells 2022, 11, 2065. https://doi.org/10.3390/cells11132065
Mia MM, Singh MK. New Insights into Hippo/YAP Signaling in Fibrotic Diseases. Cells. 2022; 11(13):2065. https://doi.org/10.3390/cells11132065
Chicago/Turabian StyleMia, Masum M., and Manvendra K. Singh. 2022. "New Insights into Hippo/YAP Signaling in Fibrotic Diseases" Cells 11, no. 13: 2065. https://doi.org/10.3390/cells11132065