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Article

FBP2—A New Player in Regulation of Motility of Mitochondria and Stability of Microtubules in Cardiomyocytes

Department of Molecular Physiology and Neurobiology, University of Wrocław, Sienkiewicza 21, 50-335 Wrocław, Poland
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Academic Editor: Pavel Dráber
Cells 2022, 11(10), 1710; https://doi.org/10.3390/cells11101710
Received: 21 April 2022 / Revised: 18 May 2022 / Accepted: 19 May 2022 / Published: 21 May 2022
(This article belongs to the Special Issue Multitasking Proteins and Their Involvement in Pathogenesis)
Recently, we have shown that the physiological roles of a multifunctional protein fructose 1,6-bisphosphatase 2 (FBP2, also called muscle FBP) depend on the oligomeric state of the protein. Here, we present several lines of evidence that in HL-1 cardiomyocytes, a forced, chemically induced reduction in the FBP2 dimer-tetramer ratio that imitates AMP and NAD+ action and restricts FBP2-mitochondria interaction, results in an increase in Tau phosphorylation, augmentation of FBP2-Tau and FBP2-MAP1B interactions, disturbance of tubulin network, marked reduction in the speed of mitochondrial trafficking and increase in mitophagy. These results not only highlight the significance of oligomerization for the regulation of FBP2 physiological role in the cell, but they also demonstrate a novel, important cellular function of this multitasking protein—a function that might be crucial for processes that take place during physiological and pathological cardiac remodeling, and during the onset of diseases which are rooted in the destabilization of MT and/or mitochondrial network dynamics. View Full-Text
Keywords: FBP2; mitochondrial motility; microtubule stability; HL-1 cardiomyocytes; Tau; MAP1B FBP2; mitochondrial motility; microtubule stability; HL-1 cardiomyocytes; Tau; MAP1B
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MDPI and ACS Style

Pietras, Ł.; Stefanik, E.; Rakus, D.; Gizak, A. FBP2—A New Player in Regulation of Motility of Mitochondria and Stability of Microtubules in Cardiomyocytes. Cells 2022, 11, 1710. https://doi.org/10.3390/cells11101710

AMA Style

Pietras Ł, Stefanik E, Rakus D, Gizak A. FBP2—A New Player in Regulation of Motility of Mitochondria and Stability of Microtubules in Cardiomyocytes. Cells. 2022; 11(10):1710. https://doi.org/10.3390/cells11101710

Chicago/Turabian Style

Pietras, Łukasz, Ewa Stefanik, Dariusz Rakus, and Agnieszka Gizak. 2022. "FBP2—A New Player in Regulation of Motility of Mitochondria and Stability of Microtubules in Cardiomyocytes" Cells 11, no. 10: 1710. https://doi.org/10.3390/cells11101710

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