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Co-Expression Network Analysis of Micro-RNAs and Proteins in the Alzheimer’s Brain: A Systematic Review of Studies in the Last 10 Years
Article

Co-Expression Analysis of microRNAs and Proteins in Brain of Alzheimer’s Disease Patients

1
Institute of Inflammation and Ageing, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
2
Surgical Reconstruction and Microbiology Research Centre, National Institute for Health Research, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
3
Department of Emergency Medicine, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon
4
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98165 Messina, Italy
5
Program for Neurotrauma, Neuroproteomics & Biomarkers Research, Departments of Emergency Medicine, Psychiatry, Neuroscience and Chemistry, University of Florida, Gainesville, FL 32611, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Christian Barbato
Cells 2022, 11(1), 163; https://doi.org/10.3390/cells11010163
Received: 26 November 2021 / Revised: 29 December 2021 / Accepted: 1 January 2022 / Published: 4 January 2022
Alzheimer’s disease (AD) is the most common form of dementia globally; however, the aetiology of AD remains elusive hindering the development of effective therapeutics. MicroRNAs (miRNAs) are regulators of gene expression and have been of growing interest in recent studies in many pathologies including AD not only for their use as biomarkers but also for their implications in the therapeutic field. In this study, miRNA and protein profiles were obtained from brain tissues of different stage (Braak III-IV and Braak V-VI) of AD patients and compared to matched controls. The aim of the study was to identify in the late stage of AD, the key dysregulated pathways that may contribute to pathogenesis and then to evaluate whether any of these pathways could be detected in the early phase of AD, opening new opportunity for early treatment that could stop or delay the pathology. Six common pathways were found regulated by miRNAs and proteins in the late stage of AD, with one of them (Rap1 signalling) activated since the early phase. MiRNAs and proteins were also compared to explore an inverse trend of expression which could lead to the identification of new therapeutic targets. These results suggest that specific miRNA changes could represent molecular fingerprint of neurodegenerative processes and potential therapeutic targets for early intervention. View Full-Text
Keywords: Alzheimer’s disease; microRNA profile; protein profile; co-expression analysis; Rap1 signalling Alzheimer’s disease; microRNA profile; protein profile; co-expression analysis; Rap1 signalling
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MDPI and ACS Style

Watson, C.N.; Begum, G.; Ashman, E.; Thorn, D.; Yakoub, K.M.; Hariri, M.A.; Nehme, A.; Mondello, S.; Kobeissy, F.; Belli, A.; Di Pietro, V. Co-Expression Analysis of microRNAs and Proteins in Brain of Alzheimer’s Disease Patients. Cells 2022, 11, 163. https://doi.org/10.3390/cells11010163

AMA Style

Watson CN, Begum G, Ashman E, Thorn D, Yakoub KM, Hariri MA, Nehme A, Mondello S, Kobeissy F, Belli A, Di Pietro V. Co-Expression Analysis of microRNAs and Proteins in Brain of Alzheimer’s Disease Patients. Cells. 2022; 11(1):163. https://doi.org/10.3390/cells11010163

Chicago/Turabian Style

Watson, Callum N., Ghazala Begum, Emma Ashman, Daniella Thorn, Kamal M. Yakoub, Moustafa A. Hariri, Ali Nehme, Stefania Mondello, Firas Kobeissy, Antonio Belli, and Valentina Di Pietro. 2022. "Co-Expression Analysis of microRNAs and Proteins in Brain of Alzheimer’s Disease Patients" Cells 11, no. 1: 163. https://doi.org/10.3390/cells11010163

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