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Review

Potential Therapeutic Candidates for Age-Related Macular Degeneration (AMD)

Department of Ophthalmology, University of California Irvine, Irvine, CA 92697, USA
Academic Editor: Taranjit Singh Rai
Cells 2021, 10(9), 2483; https://doi.org/10.3390/cells10092483
Received: 20 August 2021 / Revised: 2 September 2021 / Accepted: 9 September 2021 / Published: 19 September 2021
Aging contributes to the risk of development of ocular diseases including, but not limited to, Age-related Macular Degeneration (AMD) that is a leading cause of blindness in the United States as well as worldwide. Retinal aging, that contributes to AMD pathogenesis, is characterized by accumulation of drusen deposits, alteration in the composition of Bruch’s membrane and extracellular matrix, vascular inflammation and dysregulation, mitochondrial dysfunction, and accumulation of reactive oxygen species (ROS), and subsequent retinal pigment epithelium (RPE) cell senescence. Since there are limited options available for the prophylaxis and treatment of AMD, new therapeutic interventions are constantly being looked into to identify new therapeutic targets for AMD. This review article discusses the potential candidates for AMD therapy and their known mechanisms of cytoprotection in AMD. These target therapeutic candidates include APE/REF-1, MRZ-99030, Ciliary NeuroTrophic Factor (CNTF), RAP1 GTPase, Celecoxib, and SS-31/Elamipretide. View Full-Text
Keywords: age-related macular degeneration (AMD); retina; AMD therapeutics age-related macular degeneration (AMD); retina; AMD therapeutics
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MDPI and ACS Style

Nashine, S. Potential Therapeutic Candidates for Age-Related Macular Degeneration (AMD). Cells 2021, 10, 2483. https://doi.org/10.3390/cells10092483

AMA Style

Nashine S. Potential Therapeutic Candidates for Age-Related Macular Degeneration (AMD). Cells. 2021; 10(9):2483. https://doi.org/10.3390/cells10092483

Chicago/Turabian Style

Nashine, Sonali. 2021. "Potential Therapeutic Candidates for Age-Related Macular Degeneration (AMD)" Cells 10, no. 9: 2483. https://doi.org/10.3390/cells10092483

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